重组人白细胞相关免疫球蛋白样受体1

产品英文名称：
Recombinant Human LA / SS-B

英文简称:
LA/SS-B

中文名称:
重组人LA/SS-B蛋白

背景资料:
The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjogren’s syndrome patients. La is involved in various aspects of RNA metabolism， including binding and protecting 3-prime UUU（OH） elements of newly RNA polymerase III - transcribed RNA， processing 5-prime and 3-prime ends of pre-tRNA precursors， acting as an RNA chaperone， and binding viral RNAs linked to hepatitis C virus. It occurs in both the nucleus and the cytoplasm， where it assumes di昆虫Sf9细胞中重组表达erent roles. In the nucleus， La protein facilitates the production of tRNAs， acting as an RNA polymerase III （RNAP III） transcription factor by attaching to the U-rich 3’UTR of nascent transcripts， aiding in their folding and maturation. In the cytoplasm， La protein facilitates the translation of specific mRNAs， acting as a translation factor. As an RNA binding protein （RBP）， La protein associates with subsets of mRNAs which contain a 5’-terminal oligopyrimidine （5’TOP） motif known to direct protein synthesis. The binding of La protein to particular classes of RNA molecules regulates their downstream processing， guards them from endonuclease digestion， and organizes their export from the nucleus. La/SS-B appears to be readily disposed to proteolysis， which results in many smaller （42kD， 320， and 270） nevertheless still immunoreactive polypeptides. La/SS-B antigen is strongly conserved across species. Anti-La/SS-B autoantibodies were originally found as precipitating autoantibodies in sera of Sjogren’s Syndrome patients and referred to as SjT. Anti-La/SS-B precipitins are most frequently found in Sjogren’s Syndrome， Systemic Lupus Erythematosus （SLE） and Subacute Cutaneous Lupus. Also， there sLA/SS-B Human Recombinant produced in SF9 is a single， glycosylated， polypeptide chain having a calculated molecular mass of 47.6 kDa， is fused to a hexahistidine purification tag. The LA/SS-B is purified by proprietary chromatographic techniques.ms to be a correlation betwLA/SS-B Human Recombinant produced in SF9 is a single， glycosylated， polypeptide chain having a calculated molecular mass of 47.6 kDa， is fused to a hexahistidine purification tag. The LA/SS-B is purified by proprietary chromatographic techniques.n anti-La/SS-B and the absence of nephritis in SLE patients.

产品描述:
LA/SS-B Human Recombinant produced in SF9 is a single， glycosylated， polypeptide chain having a calculated molecular mass of 47.6 kDa， is fused to a hexahistidine purification tag. The LA/SS-B is purified by proprietary chromatographic techniques.
来源宿主:
昆虫Sf9细胞中重组表达

序列:


溶解建议:
Sterile Filtered clear solution. The protein solution contains 20mM HEPES， pH 7.5， 400mM NaCl， 20% Glycerol.

保存建议：
Store at 4℃ if entire vial will be used within 2-4 weeks. Store， frozen at -20℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。