胶质纤丝蛋白

产品英文名称：
Recombinant Human Polymerase II Polypeptide J2

英文简称:
POLR2J2

中文名称:
重组人聚合酶II多肽J2

背景资料:
POLR2J2 belongs to the RNA polymerase II subunit 11 gene family， that includes 3 genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. DNA directed RNA polymerase II polypeptide J family encodes a subunit of RNA polymerase II， the polymerase which is responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple， otherwise spliced transcripts which express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3’ end that makes them candidates for nonsense-mediated decay（NMD). Therefore， it is unknown if this locus expresses a protein or proteins in vivo.

产品描述:
POLR2J2 belongs to the RNA polymerase II subunit 11 gene family， that includes 3 genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. DNA directed RNA polymerase II polypeptide J family encodes a subunit of RNA polymerase II， the polymerase which is responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple， otherwise spliced transcripts which express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3’ end that makes them candidates for nonsense-mediated decay（NMD). Therefore， it is unknown if this locus expresses a protein or proteins in vivo.
来源宿主:
大肠杆菌中重组表达

序列:
MGSSHHHHHH SSGLVPRGSH MGSMNAPPAF ESFLLFEGEK ITINKDTKVP KACLFTINKE DHTLGNIIKS QLLKDPQVLF AGYKVLE HKIIIRVQTT PDYSPQEAFT NAITDLISEL SLLEERFRTC LLPLRLLP.

溶解建议:
提供的重组人聚合酶II多肽J2产品形式为无菌的无色溶液.

保存建议：
人聚合酶II多肽J2蛋白产品可整瓶4℃保存2-4周，长期保存请置于-20℃.推荐添加载体蛋白（0.1% HSA或BSA)以长期保存，请避免反复冻融.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。