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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
2-8度
- 保质期：
1年
- 英文名：
SMAD2
- 库存：
999
- 供应商：
上海淳麦
- 规格：
/5ug/20ug/1mg
Recombinant Human SMAD Family Member 2
英文简称:
SMAD2
中文名称:
重组人SMAD家族成员2
背景资料:
SMAD2 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. Phosphorylated SMAD2 is then able to form a complex with SMAD4 or SARA. These complexes accumulate in the cell nucleus， where they are directly participating in the regulation of gene expression. SMAD2 mediates the signal of the TGF-beta， and therefore regulates multiple cellular processes， such as cell proliferation， apoptosis， and di大肠杆菌中重组表达erentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation （SARA） protein. TGF-beta 1 acts on adjacent stromal cells to turn on SMAD2 signalling that could lead to stromal decidualization. SMAD2 is the downstream signal transducers of TGF-beta-1 in human dental pulp cells.
产品描述:
SMAD2 Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 487 amino acids （1-467） and having a molecular mass of 54.4 kDa. SMAD2 is fused to 20 amino acid His-Tag at N-Terminus and purified by standard chromatography techniques.
来源宿主:
大肠杆菌中重组表达
序列:
MGSSHHHHHH SSGLVPRGSH MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE LEKAITTQNC NTKCVTIPSTCSEIWGLSTP NTIDQWDTTG LYSFSEQTRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLVPRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG ETSDQQLNQS MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYYELNQRVGETF HASQPSLTVD GFTDPSNSER FCLGLLSNVN RNATVEMTRR HIGRGVRLYY IGGEVFAECL SDSAIFVQSP NCNQRYGWHP ATVCKIPPGCNLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK GWGAEYRRQT VTSTPCWIEL HLNGPLQWLD KVLTQMGSPS VRCSSMS.
溶解建议:
Sterile Filtered colorless solution. The SMAD2 protein solution contains 20mM Tris-HCl pH-8， and 100mM NaCl.
保存建议：
SMAD2 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
其他简介：
ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。
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文献和实验Molecular Detection of Smad2/Smad4 Alterations in Colorectal Tumors
The signaling pathways mediated by the transforming growth factor-β (TGF-β) family of factors are implicated in a wide array of biological processes including cell differentiation and proliferation, determination of cell fate during embryogenesis
【求助】请问激活SMAD通路，samd表达上升还是其磷酸化？
hhyy601 我是细胞生物的外行，我现在请教各问题，通过SMAD信号通路，是使samd2/3磷酸化还是使samd2/3表达上升？ MIRNA下降是使samd2/3磷酸化还是表达上升，表达上升激活了这个通路吗？谢谢 zfv2007 1. smad2/3是转录因子，受到上游通路激活后发生磷酸化，然后入核调控相应靶基因的转录，所以激活应该是smad2/3的磷酸化增加。 2.在其他条件不变的情况下，smad2/3表达
Bioluminescence Analysis of Smad-Dependent TGF- Signaling in Live Mice
TGF-β signaling via the Smad2/3 pathway has key roles in development and tissue homeostasis. Perturbations of the TGF-β signaling are involved in the pathogenesis of many human diseases, including cancer, fibrotic disorders, developmental
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