Ubiquitin GST

产品英文名称：
Recombinant Human Natural Cytotoxicity Receptor NKp46

英文简称:
NKp46

中文名称:
重组人自然细胞毒性受体NKp46

背景资料:
A natural cytotoxicity receptor （NCR） NKp46 has bNKp46 Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 235 amino acids and having a molecular mass of 26.6 kDa.n shown to represent a novel NK cell-specific molecule involved in human NK cell activation. The natural cytotoxicity receptors （NCRs） are a recently characterized family of Ig-like activation receptors that appear to be major triMQQQTLPKPF IWAEPHFMVP KEKQVTICCQ GNYGAVEYQL HFEGSLFAVD RPKPPERINKVKFYIPDMNS RMAGQYSCIY RVGELWSEPS NLLDLVVTEM YDTPTLSVHP GPEVISGEEV TFYCRLDTAT SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV TTAHRGTYRX FGSYNNHAWSFPSEPVKLLV TGDIENTSLA PEDPTFSADT WGTYLLTTET GLQKDHALWD HTAQN.ering receptors in tumor cell recognition. The thrNKp46 Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 235 amino acids and having a molecular mass of 26.6 kDa. known NCRs include NKp46 and NKp30， which are expressed on circulating NKcells， and NKp44， which is expressed only on activating NK cells. NKp46 has bNKp46 Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 235 amino acids and having a molecular mass of 26.6 kDa.n implicated in NK cell-mediated lysis of several autologous tumor cells， pathogen-infected cell lines and mononuclear phagocytes infected with an intracellular bacterium. The Lysis of tumor cells by NK-cells involves recognition by NKp46 of heparan sulfate moieties of membrane heparan sulfate proteoglycans. Furthermore， NKp46 is a surface receptor involved in NK-cell cell death by apoptosis. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region， a type I transmembrane domain， and a short cytoplasmic tail. The extracellular Ig-like domain of NKp46 （22-255aa） is purified by FPLC gel-filtration chromatography， after refolding of the isolated inclusion bodies in a redox bu大肠杆菌中重组表达er. In addition， engagement of the antigen with the monoclonal antibody stimulates intracellular calcium levels and the synthesis of cytokines. CD59 is an NKp46 coreceptor （by physical association） together they activate cytotoxicity of human NK-cells， their engagement results in tyrosine phosphorylation of CD3-zeta chains associated with NKp46. Reduced cell surface expression of NKp46 and other NK-cell receptors is linked to the impaired NK-cell cytolytic function in viremic HIV-1 infection.

产品描述:
NKp46 Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 235 amino acids and having a molecular mass of 26.6 kDa.
来源宿主:
大肠杆菌中重组表达

序列:
MQQQTLPKPF IWAEPHFMVP KEKQVTICCQ GNYGAVEYQL HFEGSLFAVD RPKPPERINKVKFYIPDMNS RMAGQYSCIY RVGELWSEPS NLLDLVVTEM YDTPTLSVHP GPEVISGEEV TFYCRLDTAT SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV TTAHRGTYRX FGSYNNHAWSFPSEPVKLLV TGDIENTSLA PEDPTFSADT WGTYLLTTET GLQKDHALWD HTAQN.

溶解建议:
Sterile filtered colorless solution. The protein contains phosphate buffered saline （pH7.4） & 1mM EDTA.

保存建议：
Store at 4℃ if entire vial will be used within 2-4 weeks. Store， frozen at -20℃ for longer periods of time. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Avoid multiple freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。