产品英文名称: Recombinant Human Stromal Cell-Derived Factor-1 beta (CXCL12)
英文简称: SDF 1b
中文名称: 重组人基质细胞衍生因子-1β
背景资料: SDF-1 (stromal cell-derived factor-1) is small cytokine belonging to the chemokine family that is o大肠杆菌中重组表达icially designated Chemokine (C-X-C motif) ligand 12 (CXCL12). It is produced in two forms, SDF-1?/CXCL12a and SDF-1?/CXCL12b, by alternate splicing of the same gene. Chemokines are characterized by the presence of four conserved cysteines, which form two disulfide bonds. The CXCL12 proteins belong to the group of CXC chemokines, whose initial pair of cysteines are separated by one intervening amino acid. CXCL12 is strongly chemotactic for lymphocytes and has b人基质细胞衍生因子-1β重组蛋白是在大肠杆菌中重组表达的,是一条非糖基化的多肽链,包含有72个氨基酸,分子量为8508Da.该人基质细胞衍生因子-1β重组蛋白最终由标准的色谱技术纯化出.n implicated as an important cell co-ordinator during development. During embryogenesis it directs the migration of hematopoietic cells from foetal liver to bone marrow. Mice which were knocked-out for CXCL12 gene were lethal before the birth or within just 1 hour of life. As another role, CXCL12a alters also the electrophysiology of neurons. CXCL12 was shown to be expressend in many tissues in mice (including brain, thymus, heart, lung, liver, kidney, spl人基质细胞衍生因子-1β重组蛋白是在大肠杆菌中重组表达的,是一条非糖基化的多肽链,包含有72个氨基酸,分子量为8508Da.该人基质细胞衍生因子-1β重组蛋白最终由标准的色谱技术纯化出.n and bone marrow).The receptor for this chemokine is CXCR4, which was previously called fusin. This CXCL12-CXCR4 interaction used to be considered exclusive (unlike for other chemokines and their receptors), but recently it was suThe sequence of the first five N-terminal amino acids was determined and was found to be Lys-Pro-Val-Ser-Leu.ested that CXCL12 is also bound by CXCR7 receptor.The gene for CXCL12 is located on human chromosome 10. In human and mouse both CXCL12 and CXCR4 show high identity of sequence: 99% and 90%, respectively.