Caspase-2 assay kit for drug d

Target Validation in Drug Discovery

from the area of oncology target validation. The Akt signal transduction pathway is used to illustrate an efficient way of identifying HCS compatible reagents for use in assay development. RNAi transfection methods are discussed. A description is given of an HCS

Target-Based Antimicrobial Drug Discovery

. While current agents have emerged almost exclusively from whole-cell screening of natural products and small molecules that cause microbial death, recent advances in target identification and assay development have resulted in a flood of target-driven drug

Drug Discovery Through Functional Screening in the Drosophila Heart

chemical genetics, which has the advantages that complement classical reverse genetics and should advance efforts at drug discovery for many diseases. Toward that end an appropriate biological assay system is required to describe specific heart phenotypes