- ¥798
- BD
- 561689
- USA
- 2025年09月20日
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海研卉生物科技有限公司
- 保存条件：
低温
- 库存：
询问
- 抗体英文名：
PE Rat Anti-CD11b
- 规格：
25 ug
BD Pharmingen
Alternative Name
Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
Concentration
0.2 mg/ml
Isotype
Rat DA, also known as DA/HA IgG2b, κ
Reactivity
Mouse (QC Testing) Human (Tested in Development)
Application
Flow cytometry (Routinely Tested)
Immunogen
Mouse Splenic Cells
Entrez Gene ID
16409
Description
The M1/70 monoclonal antibody specifically binds to CD11b, also known as Integrin alpha M (Itgam or αM). CD11b is a 170-kDa type 1 transmembrane glycoprotein and belongs to the Integrin alpha chain family. CD11b serves as the alpha chain of the heterodimeric Mac-1 integrin (CD11b/CD18, αMβ2), also known as complement receptor 3 (CR3). Mac-1 mediates adhesion to ICAM-1 (CD54), ICAM-2 (CD102), fibrinogen and binding to C3bi. Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 B lymphocytes. Mac-1 expression is rapidly upregulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. The M1/70 antibody reportedly blocks cell adherence and C3bi binding but does not block cell-mediated lysis. Cross-reaction of the M1/70 antibody with CD11b expressed on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported.
Format
- Format
- PE
- Excitation Source
- Blue 488 nm,Green 532 nm,Yellow/Green 561 nm
- Excitation Max
- 496 nm
- Emission Max
- 578 nm
R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae. It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule. This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.
Suggested Companion Products
| Cat No. | Description | Size | |
|---|---|---|---|
| 553989 | PE Rat IgG2b, κ Isotype Control RUO | 0.1 mg |
|
| 554656 | Stain Buffer (FBS) RUO | 500 mL |
|
| 554657 | Stain Buffer (BSA) RUO | 500 mL |
|
| 553311 | PE Rat Anti-CD11b M1/70 RUO | 0.2 mg |
|
| 561689 | PE Rat Anti-CD11b M1/70 RUO | 25 mg |
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