- ￥99 - 999
- Sigma
- 进口
- G1774-.1mg
- 2025年12月16日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
RT
- 保质期：
见标签
- 库存：
999
- 供应商：
联硕生物
- CAS号：
16941-32-5
- 规格：
0.10mg
说明
Amino Acid Sequence
His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
一般描述
Glucagon (GCG) peptide is secreted in response to insulin from pancreatic islets α-cells.[1]
Glucagon is synthesized from proglucagon and is 29-amino acid peptide hormone.[2] Proglucagon gene is mapped to human chromosome 2q24.2.[3]
应用
Glucagon (GCG) has been:
used as a component of hormone stock solution for preserving full biological activity of heart tissues obtained from male Sprague-Dawley rats[1]
used as an infusion in phases II and III fasting king penguins to study the various lipolytic, metabolic, and hormonal responses[4]
used for the stimulation of PGC-1α expression in hepatocytes[5]
used to induce the expression of methionine adenosyltransferase α1 (MAT1A), which is involved in the regulation of hepatic levels of S-adenosylmethionine and the adaptive response to fasting[6]
used to study its effect on stimulation of gluconeogenesis through hepatic lipolysis, mediated by inositol trisphosphate receptor 1 (INSP3R1)[7]
intraperitoneally injected in mice to assess glucagon-induced Sam68 subcellular localization in vivo[8]
生化/生理作用
Glucagon (GCG) produces elevation in contractility and the frequency of contraction in heart muscles. It activates PI3K (phosphoinositide 3-kinase) and thus, elevates glucose utilization by heart muscles.[1] In multiple mammals, though not humans, this peptide induces lipolysis, and is the major lipolytic hormone in birds. It also induces gluconeogenesis and glycogenolysis in mammals and birds.[4]
The paired box 6 (PAX6) regulates the expression of glucagon.[9] High levels of glucagon referred to as hyperglucagonemia leads to a high risk of diabetes and is associated with pancreatic neuroendocrine tumors.[2] Defective glucagon hypersecretion is regarded as an etiopathogenic factor.[9]
组分
H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH.xHCl
其他说明
Lyophilized from 0.1% TFA in H2O
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文献和实验处理： 1、早期低血糖仅有出汗、心慌、乏力、饥饿等症状，神志清醒时，可给病人饮用糖水，或进食含糖较多的饼干或点心。 2、如病人神志已发生改变，应该用50%葡萄糖40-60ml静脉注射，更严重时，可用10%萄萄糖持续静脉滴注。 3、胰高血糖素的应用 有条件可用胰高血糖素1mg肌内注射，但胰高血糖素价格较高。 需要注意的是，用拜糖平治疗的病人如发生低血糖则需用葡萄糖口服或静脉应用治疗。
乙醇（ 3 ） 0.5 ml / L KOH 溶液（ 4 ） 0.1 mol / L HCl 溶液（5） 碘试剂：称取碘化钾 2.0g， 溶于少量蒸馏水，再加碘 0.2g， 待溶解后用蒸馏水稀释定容至 l00ml.（6） 直链淀粉标准液：称取直链淀粉纯品 0.1000g， 放在 100ml 容量瓶中，加入 0.5mol/ L KOH 10ml， 在热水中待溶解后，取出加蒸馏水定容至 100ml， 即为 1mg/ml 直链淀粉标准溶液。 （7） 支链淀粉标准液：用 0.1000g 支链淀粉按 （6） 法制备成 1mg
常用的微量蛋白质快速测定方法。 考马斯亮蓝G-250染液的配制：称取100mg考马斯亮蓝G-250，溶于50mL 90％乙醇中，加入85％（W／V）的磷酸100mL，最后用蒸馏水定容到1000mL。此溶液在常温下可放置一个月。 采用Bradfold法进行蛋白定量，以1 mg/mlBSA 制作标准曲线。 首先，配1mg/ml BSA(1mg BSA溶于1ml三蒸水)，按下表配置梯度浓度的标准溶液。 浓度
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