Anti-CARD8 antibody

Anti-CARD8 antibody

Cat. No.     JC222031
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-CARD8 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human CARD8
Reactivity                 Human
Content                     0.6 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 CARD8
Full name                 caspase recruitment domain family, member 8
Synonyms    NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL
Swissprot    Q9Y2G2

Target Background
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis.

Applications
Immunohistochemistry
Predicted cell location: Nucleus and Cytoplasm
Positive control: Human thyroid cancer
Recommended dilution: 25-100    Predicted cell location: Nucleus and Cytoplasm
Positive control: Human brain
Recommended dilution: 25-100