Anti-PAK6 antibody

Anti-PAK6 antibody

Cat. No.     JC221097
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-PAK6 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human PAK6
Reactivity                 Human, Mouse
Content                     0.4 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 PAK6
Full name                 p21 protein (Cdc42/Rac)-activated kinase 6
Synonyms    PAK5
Swissprot    Q9NQU5

Target Background
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human ovarian cancer
Recommended dilution: 50-100    Predicted cell location: Cytoplasm
Positive control: Human thyroid cancer
Recommended dilution: 50-100