Product overview
Description Anti-ARFGEF1 rabbit polyclonal antibody
Applications ELISA, WB, IHC
Immunogen Synthetic peptide of human ARFGEF1
Reactivity Human, Mouse, Rat
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol ARFGEF1
Full name ADP ribosylation factor guanine nucleotide exchange factor 1
Synonyms BIG1; P200; ARFGEP1
Swissprot Q9Y6D6
Target Background
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition.