Product overview
Description Anti-CDKN2A rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human CDKN2A
Reactivity Human
Content 1 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-CDKN2A antibody Target information
Symbol CDKN2A
Full name cyclin-dependent kinase inhibitor 2A
Synonyms ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A
Swissprot P42771
Target Background
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.
Anti-CDKN2A antibody Applications
Immunohistochemistry
Predicted cell location: Cytoplasm or Nucleus
Positive control: Human brain
Recommended dilution: 50-200 Predicted cell location: Cytoplasm or Nucleus
Positive control: Human thyroid cancer
Recommended dilution: 50-200