Anti-CDKN2A antibody

Anti-CDKN2A antibody

Cat. No.   JC161550     
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-CDKN2A rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human CDKN2A
Reactivity                 Human
Content                     1 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-CDKN2A antibody
Target information
Symbol                 CDKN2A
Full name                 cyclin-dependent kinase inhibitor 2A
Synonyms    ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A
Swissprot    P42771

Target Background
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.

Anti-CDKN2A antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm or Nucleus
Positive control: Human brain
Recommended dilution: 50-200    Predicted cell location: Cytoplasm or Nucleus
Positive control: Human thyroid cancer
Recommended dilution: 50-200