Anti-GRB2 antibody

Anti-GRB2 antibody

Cat. No.     JC220710
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-GRB2 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Full length fusion protein
Reactivity                 Human, Mouse, Rat
Content                     0.3 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 GRB2
Full name                 growth factor receptor-bound protein 2
Synonyms    ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2
Swissprot    P62993

Target Background
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications
Immunohistochemistry
Predicted cell location: Cytoplasm and Nucleus
Positive control: Human esophagus cancer
Recommended dilution: 10-50    Predicted cell location: Cytoplasm and Nucleus
Positive control: Human tonsil
Recommended dilution: 10-50