Product overview
Description Anti-MANF rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human MANF
Reactivity Human, Mouse, Rat
Content 0.602 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-MANF antibody Target information
Symbol MANF
Full name mesencephalic astrocyte-derived neurotrophic factor
Synonyms ARP; ARMET
Swissprot P55145
Target Background
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.
Anti-MANF antibody Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human thyroid cancer
Recommended dilution: 100-300 Predicted cell location: Cytoplasm
Positive control: Human colon cancer
Recommended dilution: 100-300