Anti-TPMT antibody

Anti-TPMT antibody

Cat. No.     JC125354        
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-TPMT rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human TPMT
Reactivity                 Human
Content                     1.08 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-TPMT antibody
Target information
Symbol                 TPMT
Full name                 thiopurine S-methyltransferase
Synonyms    TPMTD
Swissprot    P51580

Target Background
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.

Anti-TPMT antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human cervical cancer
Recommended dilution: 40-200