- ¥2980
- LMAI Bio
- LM-13752R-FITC
- 中国/美国/欧洲
- 2025年07月16日
- ICC=1:50-200 IF=1:50-200
- Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep,
- Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep,
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- 详细信息
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 靶点：
详见说明书
- 级别：
1
- 目录编号：
LM-13752R-FITC
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Anti-Claudin 16/FITC
- 抗体名：
Anti-Claudin 16/FITC
- 标记物：
FITC标记
- 宿主：
Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep,
- 适应物种：
Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep,
- 免疫原：
详见说明书
- 亚型：
IGg
- 形态：
粉末、液体、冻干粉
- 应用范围：
ICC=1:50-200 IF=1:50-200
- 浓度：
1mg/ml
- 保存条件：
-20 °C
- 规格：
100ul
FITC标记的紧密连接蛋白16抗体
| 英文名称 | Anti-Claudin 16/FITC |
| 中文名称 | FITC标记的紧密连接蛋白16抗体 |
| 别 名 | Claudin 16; Claudin-16; CLD16_HUMAN; CLDN 16; Cldn16; Paracellin 1; Paracellin-1; PCLN-1; PCLN 1; PCLN1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞粘附分子 内皮细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 34kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Claudin 16 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Tight junctions mediate the regulation of the paracellular pathway between epithelial and endothelial cells. They form close connections to eliminate the extracellular space and regulate the flow of solutes between cells. The human gene PCLN-1 (paracellin-1) is related to the claudin family of integral membrane proteins, which localize to tight junctions. PCLN-1 contains four transmembrane domains and intracellular amino and carboxy termini, characteristic of the other claudin family members, and is detected only at the tight junctions of kidney tissue. PCLN-1 forms an intercellular pore and controls the resorption of magnesium and calcium in the thick ascending limb of Henle (TAL). Mutations in PCLN-1 cause renal magnesium wasting, which may contribute to a rare autosomal recessive disease, renal hypomagnesemia with hypercalciuria and nephrocalcinosis. Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors. Subcellular Location: Cell junction; tight junction. Cell membrane. Tissue Specificity: Kidney-specific, including the thick ascending limb of Henle (TAL). DISEASE: Defects in CLDN16 are the cause of hypomagnesemia type 3 (HOMG3) [MIM:248250]; also known as familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC). HOMG3 is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis. Recurrent urinary tract infections and kidney stones are often observed. In spite of hypercalciuria, patients do not show hypocalcemia. Similarity: Belongs to the claudin family. Database links: Entrez Gene: 10686 Human Entrez Gene: 114141 Mouse Entrez Gene: 155268 Rat Omim: 603959 Human SwissProt: Q9Y5I7 Human SwissProt: Q14BW2 Mouse SwissProt: Q925N4 Mouse SwissProt: Q91Y55 Rat Unigene: 251391 Human Unigene: 275205 Mouse Unigene: 43852 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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FITC标记的紧密连接蛋白16抗体
¥2980
