FITC标记的丝裂原活化蛋白激酶相互作用蛋白3抗体

FITC标记的丝裂原活化蛋白激酶相互作用蛋白3抗体

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  • ¥2980
  • LMAI Bio
  • LM-13648R-FITC
  • 中国/美国/欧洲
  • 2025年06月27日
  • ICC=1:50-200 IF=1:50-200
  • Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
  • Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
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    • 详细信息
    • 技术资料
    • 供应商

      上海联迈生物工程有限公司

    • 库存

      大量

    • 靶点

      详见说明书

    • 级别

      1

    • 目录编号

      LM-13648R-FITC

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      1年

    • 抗体英文名

      Anti-JIP3/FITC

    • 抗体名

      Anti-JIP3/FITC

    • 标记物

      FITC标记

    • 宿主

      Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,

    • 适应物种

      Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,

    • 免疫原

      详见说明书

    • 亚型

      IGg

    • 形态

      粉末、液体、冻干粉

    • 应用范围

      ICC=1:50-200 IF=1:50-200

    • 浓度

      1mg/ml

    • 保存条件

      -20 °C

    • 规格

      100ul

    FITC标记的丝裂原活化蛋白激酶相互作用蛋白3抗体
    英文名称 Anti-JIP3/FITC
    中文名称 FITC标记的丝裂原活化蛋白激酶相互作用蛋白3抗体
    别    名 C-jun-amino-terminal kinase-interacting protein 3; FLJ00027; Homolog of Drosophila Sunday driver 2; JIP-3; JIP3_HUMAN; JNK / Stress Activated Protein Kinase Associated Protein 1; JNK Interacting Protein 3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; KIAA1066; MAPK8IP3; Mitogen Activated Protein kinase 8 Interacting Protein 3; Mitogen-activated protein kinase 8-interacting protein 3.  
    规格价格 100ul/2980元 购买        大包装/询价
    说 明 书 100ul  
    研究领域 心血管  细胞生物  神经生物学  信号转导  激酶和磷酸酶  细胞骨架  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, 
    产品应用 ICC=1:50-200 IF=1:50-200  
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 147kDa
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human JIP3
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    产品介绍 background:
    The JNK-interacting proteins (JIPs) are a family of scaffold proteins that mediate JNK signaling by organizing specific components of the MAPK cascade together to form a functional JNK signaling molecule. JIP-3 (JNK-interacting protein 3), also known as JSAP1 or MAPK8IP3 (Mitogen-activated protein kinase 8-interacting protein 3), is a 1,336 amino acid protein that localizes to the cytoplasm and belongs to the JIP family. Expressed in a variety of tissues, including brain and heart, JIP-3 forms homo- or heterooligomeric complexes that can interact with several components of the JNK signaling pathway, thereby functioning as a regulator of kinesin-dependent axonal transport that may also play a role in scaffold formation within neuronal cells. Human JIP-3, which may be phosphorylated upon DNA damage, shares 69% similarity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of JIP-3 exist due to alternative splicing events.

    Function:
    The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interations 

    Subcellular Location:
    Cytoplasm.

    Post-translational modifications:
    Phosphorylated upon DNA damage, probably by ATM or ATR.

    Similarity:
    Belongs to the JIP scaffold family.

    Database links:

    Entrez Gene: 23162 Human

    Entrez Gene: 30957 Mouse

    Omim: 605431 Human

    SwissProt: Q9UPT6 Human

    SwissProt: Q9ESN9 Mouse

    Unigene: 207763 Human

    Unigene: 43081 Mouse



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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