Product overview
Description Anti-CASP9 (active) rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human CASP9 (active)
Reactivity Human, Mouse
Content 0.5 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol CASP9 (active)
Full name caspase 9, apoptosis-related cysteine peptidase
Synonyms MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; CASPASE-9c
Swissprot P55211
Target Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms.