Anti-MTA3 antibody

Anti-MTA3 antibody

Cat. No.     JC263074
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-MTA3 rabbit polyclonal antibody
Applications        ELISA, WB 
Immunogen               Synthetic peptide of human MTA3
Reactivity                 Human, Mouse
Content                     0.5 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 MTA3
Full name                 metastasis associated 1 family member 3
Synonyms    
Swissprot    Q9BTC8

Target Background
Metastasis-associated protein 3 (MTA3) is a subunit of the Mi-2/NuRD transcriptional corepressor complex. MTA3 and the Mi-2/NuRD complex mediate repression of Snail in breast cancer cells where MTA3 works to maintain a differentiated, epithelial status. The protein is involved in gene expression regulation by covalent modifications of histone proteins. There are two known isoforms of MTA3, a short and a long form. The short isoform binds to ER and sequesters it to the cytoplasm and betters non-genomic responses, whereas the long form is found in the nucleus. MTA3 is widely expressed with highest expression in brain, adrenal glands, ovaries and virgin mammary glands. It has been found to be expressed in higher levels in tumors than in adjacent normal tissue in the same individual.

Applications
Western blotting
Predicted band size:67 kDa
Positive control:Jurkat cell lysate 
Recommended dilution: 200-1000