Anti-RRP8 antibody

Anti-RRP8 antibody

Cat. No.    JK125896 
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-RRP8 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human RRP8
Reactivity                 Human, Mouse, Rat
Content                     1.26 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 RRP8
Full name                 ribosomal RNA processing 8
Synonyms    NML; KIAA0409
Swissprot    O43159

Target Background
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.