- 询价
- Signalway Antibody
- USA
- AP79497
- 2025年07月11日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
NF-kappa-B essential modulator
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:>90% by SDS-PAGE
specificity:Human
other_names:FIP3,NEMO,FIP-3,IkB kinase-associated protein 1,Inhibitor of nuclear factor kappa-B kinase subunit gamma,NF-kappa-B essential modifier,IKKAP1,I-kappa-B kinase subunit gamma
accession_no:Q9Y6K9
Gene name:IKBKG
calculated_mw:
tag info:His
Immunogen Description:Recombinant protein
formulation:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
storage:Store at -20C. (Avoid repeated freezing and thawing.)
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
产品详细信息请点击：NF-kappa-B essential modulator
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文献和实验commercially or synthesized at a core facility)—the following sequences can be used: NF‐κB = 5′‐AGTTGAGGGGACTTTCCCAGGC‐3′; consensus sequence (Promega Corp., cat. no. E3291
accumulation by LPS, as TLR4 can use either MyD88 or TRIF. The net result of these interactions was activation of the transcription factors NF-{kappa}B and AP-1, and synthesis of TNF-{alpha} mRNA. TNF-{alpha} acts through an apparent autocrine pathway
. The activity of these targets leads to survival, cytoskeletal rearrangement and transformation. GSK3 β lycogen synthase kinase-3; NF-κB, nuclear factor of κB; PDK1/2, 3-phosphoinositide-dependent protein kinase 1/2.
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