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- Signalway Antibody
- USA
- AP78926
- 2025年07月13日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Multiple inositol polyphosphate phosphatase 1
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:>90% by SDS-PAGE
specificity:Human
other_names:UNQ900/PRO1917,MIPP,3.1.3.80,2,3-bisphosphoglycerate 3-phosphatase,Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase,2,3-BPG phosphatase,Ins(1,3,4,5)P(4) 3-phosphatase
accession_no:Q9UNW1
Gene name:MINPP1
calculated_mw:
tag info:His
Immunogen Description:Recombinant protein
formulation:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
storage:Store at -20C. (Avoid repeated freezing and thawing.)
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy.
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文献和实验need to be strictly controlled. PtdIns(3,4,5)P 3 recruits and binds effectors that function in oncogenic signaling pathways. PtdIns(3,4,5)P 3 activates cell proliferation, growth, and migration as well as regulating insulin signaling. The inositol polyphosphate
酶PTEN(phosphatase and tensin homolog deleted on chromosome ten)和SHIP(SH2-containing inositol 5-phosphatase)负调节, 他们分别从PIP3的3´和5´去除磷酸而将其转变成PI(4,5)P2和PI(3,4)P2而降解. 迄今为止, 尚未发现下调Akt活性的特异磷酸酶, 但用磷酸酶抑制剂处理细胞后, 发现Akt的磷酸化和活性均有所增加. 最近发现Akt能被一种C末端调节蛋白(CTMP)所失活, CTMP
【申请上传】Current Protocols in Immunology
and T Cell Epitopes Using Synthetic Peptide Combinatorial Libraries Unit 9.6 Synthesis and Application of Peptide Dendrimers As Protein Mimetics Unit 9.7 Synthesis of Multiple Peptides on Plastic Pins Unit 9.8 Phage Display Selection and Analysis
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