- 询价
- Signalway Antibody
- USA
- AP78655
- 2025年07月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Apoptosis regulator Bcl-2
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:E.coli
purification:>90% by SDS-PAGE
specificity:Rat
other_names:Bcl-2
accession_no:P49950
Gene name:Bcl2
calculated_mw:25.96
tag info:His
Immunogen Description:1-236AA
formulation:50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
storage:Store at -20C. (Avoid repeated freezing and thawing.)
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.
产品详细信息请点击：Apoptosis regulator Bcl-2
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文献和实验Differential Expression of Apoptosis-Associated Genes bax and bcl-2 in Ovarian Cancer
either as inhibitors (e.g., bcl-2, bcl-xl, mcl- 1) or promoters (e.g., bcl-xs, bax, bak, bad) of apoptosis (1 -3 ). The chromosomal translocation t(14;18), leading to overexpression of the Bcl-2 protein was first described in human B-cell lymphoma (4 ). Later
Bcl-2 Family Immunohistochemistry
able to prolong survival by inhibiting programmed cell death (apoptosis) and (b) the discovery of many additional related genes/proteins some of which, like Bcl-2, inhibit apoptosis, whereas others, such as Bax, conversely promote cell death
Cell Survival and Apoptosis Assays for E1B 19K and Bcl-2 Family Members
Programmed cell death, or apoptosis, is an important event in the normal development and homeostasis of multicellular organisms (1 ). Apoptosis is regulated by a number of genes that promote or suppress cell death. The bcl-2 family of genes
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