- 询价
- Signalway Antibody
- USA
- AP78001
- 2025年07月06日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20˚C
- 英文名：
Recombinant Rat TGF-beta receptor type-2(Tgfbr2), partial
- 库存：
详询
- 供应商：
南京莱富赛
- 规格：
详询
host_species:Baculovirus
purification:Greater than 85% as determined by SDS-PAGE.
other_names:TGF-beta type II receptor Transforming growth factor-beta receptor type II
accession_no:P38438
calculated_mw:20 kDa
tag info:N-terminal 10xHis-tagged and C-terminal Myc-tagged
Immunogen Description:Expression Region:24-166aa
Sequence Info:Partial
formulation:Tris-based buffer50% glycerol
storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃,-80℃. The shelf life of lyophilized form is 12 months at -20℃,-80℃.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
background:Transmembrane serine,threonine kinase forming with the TGF-beta type I serine,threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways
产品详细信息请点击：Recombinant Rat TGF-beta receptor type-2(Tgfbr2), partial
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文献和实验Characterization of Wild‐Type Excitatory Amino Acid Ion Channel Receptors
. Influences of ions, enzymes and detergents on gamma‐aminobutyric acid‐receptor binding in synaptic membranes of rat brain. Mol. Pharmacol. 13:442‐453. Ferkany, J.W., and Coyle, J.T
Genetic and Pharmacologic Models for Type 1 Diabetes
Abstract Table of Contents Figures Literature Cited Abstract Type 1 diabetes (T1D) is characterized
Overview of Receptor Allosterism
Figure 1.21.1 Allosterism between a receptor and its G protein: the effects of GTP on the competition between [3 H] N ‐methylscopolamine and the agonist, carbachol, at the muscarinic acetylcholine M2 receptor in rat myocardial membranes. Competition
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