Anti-TWSG1 antibody

Anti-TWSG1 antibody

Cat. No.     JC123901        
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-TWSG1 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human TWSG1
Reactivity                 Human, Mouse
Content                     0.3 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-TWSG1 antibody
Target information
Symbol                 TWSG1
Full name                 twisted gastrulation BMP signaling modulator 1
Synonyms    TSG
Swissprot    Q9GZX9

Target Background
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).

Anti-TWSG1 antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm and Nucleus
Positive control: Human esophagus cancer
Recommended dilution: 25-100    Predicted cell location: Cytoplasm and Nucleus
Positive control: Human colorectal cancer
Recommended dilution: 25-100