- 询价
- Signalway Antibody
- USA
- 13045
- 2026年01月23日
- WB
- Rabbit
- Hu, Ms, Rt
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- 文献和实验
- 技术资料
- 免疫原：
A synthesized peptide derived from human HER2/ErbB2 around the phosphorylation site of Tyr1023
- 形态：
liquid
- 保存条件：
Store at -20˚C
- 克隆性：
Polyclonal
- 适应物种：
Hu, Ms, Rt
- 宿主：
Rabbit
- 应用范围：
WB
- 浓度：
1mg/ml
- 抗体英文名：
HER2/ErbB2 (Phospho-Tyr1023) Antibody
clonality:Polyclonal
specificity:Phospho-HER2/ErbB2 (Phospho-Tyr1023) Antibody detects endogenous levels of HER2/ErbB2 only when phosphorylated at Tyr1023
other_names:Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; C erb B2/neu protein; CD340; CD340 antigen; Cerb B2/neu protein; CerbB2; Erb b2 receptor tyrosine kinase 2; ERBB2; ERBB2_HUMAN; HER 2; HER 2/NEU; HER2; Herstatin; Human epidermal growth factor receptor 2; Metastatic lymph node gene 19 protein; MLN 19; MLN19; NEU; NEU proto oncogene; Neuro/glioblastoma derived oncogene homolog; Neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase type cell surface receptor HER2; Tyrosine kinase-type cell surface receptor HER2; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); V erb b2 avian erythroblastic leukemia viral oncogene homolog 2; V erb b2 avian erythroblastic leukemia viral oncoprotein 2; V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); accession_no:Swiss-Prot#:P04626
NCBI Gene ID:2064
产品详细信息请点击：HER2/ErbB2 (Phospho-Tyr1023) Antibody
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3胞内区无内在的酪氨酸激酶活性不能自身磷酸化，但ERBB3能够与表皮生长因子受体家族其它成员，ERBB1（又称EGFR，HER1）、ERBB2/HER2和ERBB4/HER4形成异源性二聚体，激活下游通路，影响细胞的增殖分化 [4]。其中ERBB3/ERBB2二聚体被认为是ERBB3二聚体中最活跃的，且活性常高于其它异源二聚体 [7]。这种异源二聚体构象使信号复合物能够激活MAPK/ERK和PI3K/AKT在内的多种通路 [8, 9]。 图2. ERBB3/ERBB2异源二聚体激活相关下游信号
运用Cell Based Elisa检测信号通路蛋白和磷酸化蛋白
using Phospho-p38 antibody (A) and Total-p38 antibody (B). Cell Based Elisa were performed directly in the 96-well plates using Phospho-p38 and Total-p38 antibodies (C). Figure 3: JNK detection with FACECells were serum-starved for 16 hours
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