Anti-RFFL antibody

Anti-RFFL antibody

Cat. No.     JC123004        
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-RFFL rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human RFFL
Reactivity                 Human, Mouse, Rat
Content                     0.2 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Anti-RFFL antibody
Target information
Symbol                 RFFL
Full name                 ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
Synonyms    CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN
Swissprot    Q8WZ73

Target Background
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation.

Anti-RFFL antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm and Cell membrane
Positive control: Human liver cancer
Recommended dilution: 25-100