Product overview
Description Anti-ALAS1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Fusion protein of human ALAS1
Reactivity Human, Mouse, Rat
Content 0.3 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Anti-ALAS1 antibody Target information
Symbol ALAS1
Full name aminolevulinate, delta-, synthase 1
Synonyms ALAS; MIG4; ALAS3; ALASH
Swissprot P13196
Target Background
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Anti-ALAS1 antibody Applications
Immunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human breast cancer
Recommended dilution: 25-100 Predicted cell location: Cytoplasm
Positive control: Human thyroid cancer
Recommended dilution: 25-100