FITC标记的去泛素化酶22抗体

FITC标记的去泛素化酶22抗体

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  • ¥2980
  • LMAI Bio
  • LM-8611R-FITC
  • 中国/美国/欧洲
  • 2025年07月08日
  • ICC=1:50-200 IF=1:50-200
  • Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, Xenopus laevis
  • Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, Xenopus laevis
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    • 详细信息
    • 技术资料
    • 供应商

      上海联迈生物工程有限公司

    • 库存

      大量

    • 靶点

      详见说明书

    • 级别

      1

    • 目录编号

      LM-8611R-FITC

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      1年

    • 抗体英文名

      Anti-USP22/FITC

    • 抗体名

      Anti-USP22/FITC

    • 标记物

      FITC标记

    • 宿主

      Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, Xenopus laevis

    • 适应物种

      Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, Xenopus laevis

    • 免疫原

      详见说明书

    • 亚型

      IGg

    • 形态

      粉末、液体、冻干粉

    • 应用范围

      ICC=1:50-200 IF=1:50-200

    • 浓度

      1mg/ml

    • 保存条件

      -20 °C

    • 规格

      100ul

    FITC标记的去泛素化酶22抗体
    英文名称 Anti-USP22/FITC
    中文名称 FITC标记的去泛素化酶22抗体
    别    名 Deubiquitinating enzyme 22; Ubiquitin carboxyl-terminal hydrolase 22; Ubiquitin thioesterase 22; Ubiquitin thiolesterase 22; Ubiquitin thiolesterase 8; Ubiquitin thiolesterase 8; Ubiquitin-specific processing protease 8; Ubiquitin-specific processing protease 8; Ubiquitin-specific-processing protease 22; UBP22_HUMAN; Usp22; USP3L.  
    规格价格 100ul/2980元 购买        大包装/询价
    说 明 书 100ul  
    研究领域 肿瘤  细胞生物  干细胞  细胞分化  表观遗传学  泛素  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, Xenopus laevis
    产品应用 ICC=1:50-200 IF=1:50-200  
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 60kDa
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human USP22
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    产品介绍 background:
    The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP22 (ubiquitin specific peptidase 22), also known as USP3L, is a 525 amino acid protein that contains one UBP-type zinc finger and functions to catalyze the conversion of a ubiquitin C-terminal thioester to free ubiquitin and thiol, a reaction that may influence several cellular processes. Via its catalytic activity, USP22 is thought to play an important role in cell cycle progression and may also serve as a cancer stem cell marker.

    Function:
    Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

    Subunit:
    Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination. Interacts directly with ATXN7L3; leading to its recritment to the SAGA complex.

    Subcellular Location:
    Nucleus.

    Tissue Specificity:
    Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver.

    Similarity:
    Belongs to the peptidase C19 family. UBP8 subfamily.
    Contains 1 UBP-type zinc finger.

    Database links:
    Entrez Gene: 23326 Human
    Entrez Gene: 216825 Mouse
    Entrez Gene: 303201 Rat
    Omim: 612116 Human
    SwissProt: Q9UPT9 Human
    SwissProt: Q5DU02 Mouse
    Unigene: 462492 Human
    Unigene: 30602 Mouse


    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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