Anti-SLC9A3R1 antibody

Anti-SLC9A3R1 antibody

Cat. No.     JK263530     
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-SLC9A3R1 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human SLC9A3R1
Reactivity                 Human, Mouse, Rat
Content                     1.02 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification


Target information
Symbol                 SLC9A3R1
Full name                 SLC9A3 regulator 1
Synonyms    EBP50; NHERF; NHERF1; NHERF-1; NPHLOP2
Swissprot    O14745

Target Background
This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.