Product overview
Description Anti-SLC9A3R1 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human SLC9A3R1
Reactivity Human, Mouse, Rat
Content 1.02 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol SLC9A3R1
Full name SLC9A3 regulator 1
Synonyms EBP50; NHERF; NHERF1; NHERF-1; NPHLOP2
Swissprot O14745
Target Background
This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm and Cell membrane
Positive control: Human brain
Recommended dilution: 10-50
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using ml263530(SLC9A3R1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)