7-H-Dibenzo(c,g)carbazole

Detection of G-Quadruplexes in Cells and Investigation of G-Quadruplex Structure of d(T2AG3)4 in K+ Solution by a Carbazole Derivative: BMVC

. We have synthesized a fluorescent probe of 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide (BMVC) that has a very high binding affinity for G-quadruplex H24. BMVC stabilizes quadruplex structures and acts as a sensitive probe to the local environment

H

） 5.00g POPOP

H-DNA

之，H-DNA是由部分未缠绕的复合DNA中的一个富嘧啶链，经回折同复合体中伸展的富嘌呤链间形成Hoogsteen氢键而形成的分子内三螺旋，即DNA的双链所形成的三链螺旋。由于形成过程中发生C→C 的转化，故称H-DNA。并把这类序列称为H回文序列。 研究还发现在毫摩尔级的Mg2 和中性pH下，d(G)30·d(C)30所形成一种由GGC三碱基体组成的嘌呤分子内三螺旋结构（H*-DNA），而另外一些研究则发现d(AG)n·d(T)n和d(G)n·d(C)n束道也能形成同时含有H-DNA和H