ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
49kDa
细胞定位
细胞膜
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated synthetic peptide derived from human Glycine Receptor alpha 1 + alpha 2
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍
background: Glycine receptors are members of the ligand-gated ion channel superfamily, which mediate fast inhibitory neurotransmission. The receptors are pentameric membrane proteins which form chloride channels. Binding of glycine to its receptor produces an increase in chloride conductance and membrane hyperpolarisation. Four genes encoding glycine receptor alpha subunits have been identified, together with a single beta polypeptide. Each subunit consists of a large extracellular N-terminal region, four transmembrane domains, and a large cytoplasmic domain.
Function: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
Subunit: Pentamer composed of alpha and beta subunits.
DISEASE: Defects in GLRA1 are the cause of hyperekplexia, hereditary, type 1 (HKPX1) [MIM:149400]. A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli.
Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
Database links:
Entrez Gene: 2741 Human
Entrez Gene: 2742 Human
Entrez Gene: 14654 Mouse
Entrez Gene: 237213 Mouse
Entrez Gene: 24397 Rat
Entrez Gene: 25674 Rat
Omim: 138491 Human
Omim: 305990 Human
SwissProt: P23415 Human
SwissProt: P23416 Human
SwissProt: Q6DJV9 Human
SwissProt: Q64018 Mouse
SwissProt: Q7TNC8 Mouse
SwissProt: P07727 Rat
SwissProt: P22771 Rat
Unigene: 121490 Human
Unigene: 2700 Human
Unigene: 113877 Mouse
Unigene: 358598 Mouse
Unigene: 10109 Rat
Unigene: 10379 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.