Oncostatin M; Oncostatin M precursor; Oncostatin-M; OSM; MGC20461; ONCM_HUMAN.
规格价格
100ul/2980元 购买 大包装/询价
说 明 书
100ul
研究领域
肿瘤 细胞生物 免疫学 转录调节因子
抗体来源
Rabbit
克隆类型
Polyclonal
交叉反应
Human, Mouse, Rat,
产品应用
IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
20kDa
细胞定位
细胞膜
性 状
Lyophilized or Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated synthetic peptide derived from human Oncostatin M
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍
background: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST).
Function: Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF. [Entrez Gene]
Subcellular Location: Secreted.
Similarity: Belongs to the LIF/OSM family.
Database links:
Entrez Gene: 5008 Human
Entrez Gene: 18413 Mouse
Entrez Gene: 289747 Rat
Omim: 165095 Human
SwissProt: P13725 Human
SwissProt: P53347 Mouse
SwissProt: Q65Z15 Rat
Unigene: 248156 Human
Unigene: 131422 Mouse
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.