Anti-MT-ND6 antibody

Anti-MT-ND6 antibody

Cat. No.     JK261927     
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-MT-ND6 rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human MT-ND6
Reactivity                 Human
Content                     0.8 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 MT-ND6
Full name                 mitochondrially encoded NADH dehydrogenase 6
Synonyms    MTND6; ND6
Swissprot    P03923

Target Background
NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Human complex I is important for energy metabolism because its main function is to transport electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits. A small number of complex I subunits are the products of mitochondrial genes (subunits 1-7), while the remainder are nuclear encoded and imported from the cytoplasm. The significance of NADH dehydrogenase subunit 6 (ND6) is rapidly becoming increasingly apparent as many mutations leading to amino acid changes in this subunit are associated with known mitochondrial diseases.