Product overview Description Anti-BCL6 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human BCL6
Reactivity Human, Mouse
Content 0.2 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information Symbol BCL6
Full name B-cell CLL/lymphoma 6
Synonyms BCL5; LAZ3; BCL6A; ZNF51; ZBTB27
Swissprot P41182
Target Background The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene