Product overview
Description Anti-NOTCH3 rabbit polyclonal antibody
Applications ELISA, IHC
Immunogen Synthetic peptide of human NOTCH3
Reactivity Human, Mouse, Rat
Content 0.6 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification
Target information
Symbol NOTCH3
Full name notch 3
Synonyms IMF2; LMNS; CASIL; CADASIL; CADASIL1
Swissprot Q9UM47
Target Background
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).