- ￥440 - 1320
- CUSABIO
- CN
- CSB-PA011112LA01HU
- 2025年07月11日
- ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant Human Immunoglobulin heavy constant alpha 2 protein (36-111AA)
- 亚型：
IgG
- 形态：
Liquid
- 保存条件：
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性：
Polyclonal
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Homo sapiens (Human)
- 目录编号：
P01877
- 级别：
优
- 库存：
200
- 供应商：
武汉华美生物工程有限公司
- 宿主：
Rabbit
- 应用范围：
ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200
- 浓度：
>95%,Protein G purified
- 靶点：
IGHA2
- 抗体英文名：
IGHA2 Antibody
- 抗体名：
IGHA2Immunoglobulin heavy constant alpha 2 antibody;Ig alpha-2 chain C region antibody;Ig alpha-2 chain C region BUT antibody;Ig alpha-2 chain C region LAN antibody
- 规格：
100μg/50μg/20μg
| 规格： | 100μg | 产品价格： | ￥1320.0 |
|---|---|---|---|
| 规格： | 50μg | 产品价格： | ￥880.0 |
| 规格： | 20μg | 产品价格： | ￥440.0 |
保存缓冲液
Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
功能
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验，克隆到表达载体中并转入宿主细胞所制备的抗体称为嵌合 抗体（ｃｈｉｍｅｒｉｃ ａｎｔｉｂｏｄｙ）。这种抗体的Ｆａｂ 区是鼠源的，Ｆｃ 区是人源的。由于整个抗体分子约 ２／３ 部分为人源的，较好地解决了ＨＡＭＡ 反应，延长了抗体在体内的半衰期，改善了抗体药物动力学。 １９８４ 年美国科学家Ｍｏｒｒｉｓｏｎ 等首次将人Ｉｇ 的Ｃ 区基因与鼠源ＭｃＡｂ 的Ｖ 区基因连接，成功表达人－鼠嵌 合抗体以来，基因工程抗体的研究发展迅速。已有多种不同特异性的基因工程抗体经ＦＤＡ 批准进入临床 使用，显示了良好
及重链和轻链之间由二硫键连接，形成的构象与英文大写字母“Y”类似。根据重链的不同将Ig分为5个同种型（isotype）,分别是IgG、IgA、IgM、IgD和IgE。其中IgG、IgD和IgE只有单体形式，而IgA和IgM具有由数个相同单体组成的多聚体形式。 图2：抗体结构示意图 Ig轻链和重链中氨基酸序列变化较大的区域称为可变区（variable region, V）,氨基酸序列较保守的区域称为恒定区（constant region, C）。重链和轻链可变区（VH和VL）各有3个区域的氨基酸组成
on the gamma1, gamma2, gamma3, and alpha2 heavy chains (they are designated as G1m, G2m, G3m, and A2m allotypes, respectively), and on the kappa light chain (Km allotypes). Gm-Am allotypes are inherited in fixed combinations, or Gm-Am haplotypes, owing
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