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FAN1抗体FAN1兔多抗抗体Myotubularin-re

lated protein 15 antibody抗体FAN1 Antibody, HRP conjugated抗体
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  • ¥880 - 1320
  • CUSABIO已认证
  • CN
  • CSB-PA22859B0Rb
  • 2025年07月12日
  • ELISA
  • Rabbit
  • Human
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Recombinant Human Fanconi-associated nuclease 1 protein (167-373AA)

    • 亚型

      IgG

    • 形态

      Liquid

    • 保存条件

      Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.

    • 克隆性

      Polyclonal

    • 标记物

      HRP

    • 适应物种

      Human

    • 保质期

      6个月

    • 抗原来源

      Homo sapiens (Human)

    • 目录编号

      Q9Y2M0

    • 级别

    • 库存

      200

    • 供应商

      武汉华美生物工程有限公司

    • 宿主

      Rabbit

    • 应用范围

      ELISA

    • 浓度

      >95%,Protein G purified

    • 靶点

      FAN1

    • 抗体英文名

      FAN1 Antibody, HRP conjugated

    • 抗体名

      Myotubularin-related protein 15 antibody

    • 规格

      100μg/50μg

    规格:100μg产品价格:¥1320.0
    规格:50μg产品价格:¥880.0

    保存缓冲液

    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

    功能

    Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).

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    该产品被引用文献
    更多文献信息可以查看cusabio官网
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    文献支持
    FAN1抗体FAN1兔多抗抗体Myotubularin-related protein 15 antibody抗体FAN1 Antibody, HRP conjugated抗体
    ¥880 - 1320