- ¥2980
- LMAI Bio
- LM-0992R-FITC
- 中国/美国/欧洲
- 2025年07月12日
- 详见说明书
- HPV16
- HPV16
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 靶点：
详见说明书
- 级别：
1
- 目录编号：
LM-0992R-FITC
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Anti-HPV16 E7/FITC
- 抗体名：
Anti-HPV16 E7/FITC
- 标记物：
FITC标记
- 宿主：
HPV16
- 适应物种：
HPV16
- 免疫原：
详见说明书
- 亚型：
IGg
- 形态：
粉末、液体、冻干粉
- 应用范围：
详见说明书
- 浓度：
1mg/ml
- 保存条件：
-20 °C
- 规格：
100ul
| 英文名称 | Anti-HPV16 E7/FITC |
| 中文名称 | FITC标记的人类乳头状瘤病毒16-E7抗体 |
| 别 名 | E7; HPV16 E7 protein; Human Papilloma Virus; Human papillomavirus type 16 E7; Human papillomavirus type 16 E7; Protein E7; Human Papillomavirus 16 (E7); HPV16 E7; E7 protein (HPV16); VE7_HPV16; HPV16-E7. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 细菌及病毒 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | HPV16 |
| 产品应用 | not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 11kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from the middle of HPV16-E7 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. Function: E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity). Subunit: Homodimer. Homooligomer. Interaction with host RB1 induces the aberrant dissociation of RB1-E2F1 complex thereby disrupting RB1's activity. Binds to CHD3 through its zinc-finger domain. Forms a complex with CHD3 and HDAC1, thereby altering the action of host histone deacetylation. A similar complex involving E7, CHD3 and HDAC2 might also form. Interacts with E2; this interaction inhibits E7 oncogenic activity. Similarity: Belongs to the papillomaviridae E7 protein family. Database links: Entrez Gene: 1489079 HPV16 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 人类乳头状瘤病毒16（HPV16-E7）是导致女性宫颈癌的主要病毒型（包括人类乳头状瘤病毒18 |
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文献和实验HPV 并不是宫颈癌唯一的「元凶」？这种微生物化身「帮凶」，共同促进癌症发生
癌基因的慢病毒转染 hCEcto（human ectocervical，人子宫颈）上皮干细胞，将 E6E7 整合到宿主细胞基因组中。结果发现，HPV16 E6E7 整合到外宫颈类器官中会诱导一种具有子宫颈上皮不典型增生（CIN，被认为是癌前病变）特征的表型。 图片来源：Nature Communications 因此，这种宫颈类器官模型的构建为研究 HPV 和共感染生物学开辟了一条途径。 沙眼衣原体与 HPV 合并感染引起独特的转录反应 为了探究宫颈中沙眼衣原体和 HPV 共感
FITC, FL2通道检测PE,则需将仪器的补偿设置为FL1-%FL2=1.10，FL2-%FL1=16.52.可以简单理解为：PE荧光染料的1.10%漏到FL1检测通道,需从FL1中减除，而FITC荧光染料的16.52%漏到FL2检测通道，需从FL2中减除。 常见荧光染料亮度比较 荧光染料的亮度可以用来比较不同荧光染料的荧光标记效果，通过阴性细胞群与阳性细胞群的荧光信号之间的关系来表示。但是阴性细胞群的荧光信号受到信号强度、自发荧光、非特异性染色、仪器的电子噪声等多个因素
概述：制定 10 色免疫表型 Panel，以鉴定人自然杀伤细胞（NK）。用于量化 NK 细胞群子集的设门策略。介绍：NK 细胞属于固有免疫系统的一部分，并与肿瘤监测和病毒感染细胞的杀伤相关。最近，有研究表明，NK 细胞在自身免疫病方面也发挥着作用，其方式为调节适应性免疫反应，即 T 细胞，或与巨噬细胞和树突细胞等其他调节细胞相互作用。我们着重对 1 型糖尿病患者与健康人体的 NK 细胞区室进行了表型和功能方面的对比。此外，我们还对比了 CD56hi/CD16lo 和 CD56lo/CD16
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