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文献和实验disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity. During learning, aged mice display a specific deregulation of histone H4 lysine 12 (H4K12) acetylation and fail to initiate a hippocampal gene expression
of precipitated chromatin are provided in Noma et al. (2001) and Gregory et al. (2001).Figure 1. Allele-specific patterns of histone modifications revealed by PCR amplification and SSCP electrophoresis. Lung tissue was dissected from a mouse
Site-directed hydroxy radical mapping of nucleosome positions in vitro
and Davey, 2003). Procedure Preparation of Derivatised Octamer Refold and purify histone octamer containing histones H2A wild type, H2B wild type, H3 Cys110Ala and H4 Ser47Cys following standard methods (Dyer et al., 2004) (see note 1);
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