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- 详细信息
- 技术资料
- 库存：
大量
- 英文名：
Amentoflavone
- CAS号：
1617-53-4
- 保质期：
2年
- 供应商：
上海瓦兰生物
- 保存条件：
常温
- 规格：
5mg/10mg/10mM*1mL
| 规格： | 5mg | 产品价格： | ￥640.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥1160.0 |
| 规格： | 10mM*1mL | 产品价格： | ￥1360.0 |
Amentoflavone 穗花杉双黄酮
产品简介
产品简介
| 别名 | 穗花杉双黄酮;阿曼托黄酮;Amentoflavone;Dideme *thyl-ginkgetin; |
| 英文名称 | Amentoflavone |
| CAS | 1617-53-4 |
| 分子式 | C30H18O10 |
| 分子量 | 538.46 |
| 外观（性状） | Light yellow to yellow-green Solid |
| 储存条件 | Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months |
| 纯度 | HPLC≥98% |
| 描述 | 是一种双黄酮类化合物,具有很多生物活性,包括抗炎、抗氧化、神经保护等作用。(It is a biflavonoid compound with many biological activities, including anti-inflammatory, antioxidant, neuroprotective and other effects.) |
| SMILES | O=C1C=C(C2=CC=C(O)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4O)C(O)=CC(O)=C13 |
| 靶点 | Reactive oxygen species (ROS) |
| 动物实验 | Animal Models: Kunming mice;Dosages: 25 mg/kg;Administration: intragastrically administered[2] |
| 细胞实验 | Approximately 2×105 MCF-7 cells/well in 24-well plates are treated with 250 μM amentoflavone, or with vehicle (DMSO, 0.1% in culture media)-only and all cells are incubated for 6 to 72 h. For the examination of morphological changes, cells are photographed under a phase-contrast microscope.[1] |
| In Vivo | In an animal model, amentoflavone is found to significantly inhibit B16F-10 melanoma-induced solid tumor development in C57BL/6 mice[1]. Amentoflavone can cross the blood-brain barrier. It effectively prevents pilocarpine-induced epilepsy in a mouse kindling model, suppresses NF-kB activation and expression, inhibits excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons[2]. |
| In Vitro | Amentoflavone induces morphological changes and reduces the percentage of viable MCF-7 cells. Amentoflavone induces apoptosis and chromatin condensation, DNA strand breaks in MCF-7 cells. Amentoflavone is also reported to induce cell-cycle arrest at the sub-G1 phase, and apoptosis via mitochondria-emanated intrinsic pathways in SiHa and CaSki human cervical cancer cells[1]. |
| 生物活性 | Amentoflavone (Dideme *thyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.[1-2] |
| 数据来源文献 | [1] Pei JS, et al. In Vivo. 2012, 26(6):963-70. [2] Zhang Z, et al. Neural Regen Res. 2015, 10(7):1125-33. |
| 溶解性 | Soluble in DMSO ≥10mg/mL |
| MDL | MFCD00017470 |
| InChIKey | YUSWMAULDXZHPY-UHFFFAOYSA-N |
| InChI | InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H |
| PubChem CID | 5281600 |
| 中文名称 | 穗花杉双黄酮 |
| 通路 | Immunology & Inflammation |
| 规格 | 5mg 10mg 10mM*1mL (in DMSO) |
| 单位 | 瓶 |
是一种双黄酮类化合物，具有很多生物活性，包括抗炎、抗氧化、神经保护等作用。
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Amentoflavone 穗花杉双黄酮
￥640 - 1360
