- ¥2980
- LMAI Bio
- LM-3618R-FITC
- 中国/美国/欧洲
- 2025年07月13日
- IF=1:50-200
- Human, Mouse, Rat, Dog, Horse,
- Human, Mouse, Rat, Dog, Horse,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 靶点：
详见说明书
- 级别：
1
- 目录编号：
LM-3618R-FITC
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Anti-HSD11B2/FITC
- 抗体名：
Anti-HSD11B2/FITC
- 标记物：
FITC标记
- 宿主：
Human, Mouse, Rat, Dog, Horse,
- 适应物种：
Human, Mouse, Rat, Dog, Horse,
- 免疫原：
详见说明书
- 亚型：
IGg
- 形态：
粉末、液体、冻干粉
- 应用范围：
IF=1:50-200
- 浓度：
1mg/ml
- 保存条件：
-20 °C
- 规格：
100ul
| 英文名称 | Anti-HSD11B2/FITC |
| 中文名称 | FITC标记的羟基类固醇脱氢酶11β2抗体 |
| 别 名 | Corticosteroid 11 beta dehydrogenase isozyme 2; 11 beta HSD2; 11 beta hydroxysteroid dehydrogenase type 2; 11 DH2; AME; AME1; HSD11K; HSD2; Hydroxysteroid 11 beta dehydrogenase 2; Hydroxysteroid 11 beta dehydrogenase isoenzyme 2; NAD dependent 11 beta hydroxysteroid dehydrogenase; SDR9C3; Short chain dehydrogenase/reductase family 9C, member 3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HSD11B2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010] Function: Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Subunit: Interacts with ligand-free cytoplasmic NR3C2. Subcellular Location: Microsome. Endoplasmic reticulum. Tissue Specificity: Found in placenta, kidney, pancreas, prostate, ovary, small intestine and colon. Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. Database links: Entrez Gene: 282434 Cow Entrez Gene: 3291 Human Entrez Gene: 15484 Mouse Entrez Gene: 396948 Pig Entrez Gene: 25117 Rat Omim: 218030 Human SwissProt: O77667 Cow SwissProt: P80365 Human SwissProt: P51661 Mouse SwissProt: P51976 Rabbit SwissProt: P50233 Rat SwissProt: P50168 Sheep Unigene: 1376 Human Unigene: 5079 Mouse Unigene: 10186 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. [DISEASE] Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME) [MIM:218030]. An autosomal recessive form of low-renin hypertension. It is usually diagnosed within the first years of life and is characterized by polyuria and polydipsia, failure to thrive, hypernatremia, severe hypertension with low renin and aldosterone levels, profound hypokalemia with metabolic alkalosis, and most often nephrocalcinosis. |
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文献和实验17β-羟基类固醇脱氢酶 17β-hydroxystero-id dehydrogenase
存在于睾丸、胎盘中。在雄性激素，发情激素的生物合成中，它是催化最终一步反应，将 17-氧基还原成 17-β羟基反应的酶。 EC1． 1． 1． 62— 63。 另外，它也存在于肝脏、肾脏、红血球、微生物中。睾丸中的酶必须选用 NADPH，而胎盘中的酶， NADH和 NAD（ PH）任何一种都有效。例如雄（甾）烯二酮 睾（甾）酮或雌酮 雌二醇 -17β
板，制成固相抗体，往包被单抗的微孔中依次加入 3β - 羟基类固醇脱氢酶Ⅰ（ 3 β HSD Ⅰ），再与 HRP 标记的 3 β - 羟基类固醇脱氢酶Ⅰ（ 3 β HSD Ⅰ）抗体结合，形成抗体 - 抗原 - 酶标抗体复合物 ，经过彻底洗涤后 加 底物TMB 显色。 TMB 在 HRP 酶的催化下转化成蓝色，并在酸的作用下转化成最终的黄色。颜色的深浅和样品中的 3β - 羟基类固醇脱氢酶Ⅰ（ 3 β HSD Ⅰ） 呈正相关。用酶标仪在 450 nm波长下测定吸光度（ OD 值）， 通过标准
加入 3α - 羟基类固醇脱氢酶（ 3 α HSD ），再与 HRP 标记的羊抗鼠抗体结合，形成抗体 - 抗原 - 酶标抗体复合物 ，经过彻底洗涤后 加 底物TMB 显色。 TMB 在 HRP 酶的催化下转化成蓝色，并在酸的作用下转化成最终的黄色。颜色的深浅和样品中的 IL-2 呈正相关。用酶标仪在 450 nm波长下测定吸光度（ OD 值）， 通过标准曲线 计算样品 中大鼠3 α - 羟基类固醇脱氢酶（ 3 α HSD ） 浓度。 试剂盒组成
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