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- 详细信息
- 文献和实验
- 技术资料
- 库存：
大量
- 英文名：
Nω-Nitro-L-arginine methyl ester hydrochloride
- CAS号：
51298-62-5
- 保质期：
2年
- 供应商：
上海瓦兰生物
- 保存条件：
2-8℃
- 规格：
250MG
性质
| Related Categories | Amino Acids & Derivatives, Application Index,Arginine, Bioactive Small Molecule Alphabetical Index, Cell Signaling Enzymes, 更多... |
| InChI Key | QBNXAGZYLSRPJK-JEDNCBNOSA |
| assay | ≥98% (TLC) |
| form | powder |
| color | white to off-white |
| solubility | H2O: 50 mg/mL |
| storage temp. | −20°C |
产品描述
包装
1, 5, 10, 25 g in poly bottle
250 mg in poly bottle
Biochem/physiol Actions
An analog of arginine that inhibits NO production. It has multiple effects on the vascular system. Inhibits relaxation induced by acetylcholine and induces an increase in arterial blood pressure. Abolishes lecithinized superoxide dismutase induced vasodilation when used to pretreat aortic ring preparations of mice. Induces leukocyte adhesion and increases microvascular fluid and protein fluxes and permeability. It has also been used in many studies of learning and memory.
Features and Benefits
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
法律信息
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
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文献和实验, benzoylecgonine-d3, ecgonine methyl ester-d3, and cocaethylene-d3 and buffered with phosphate buffer. The drugs in the sample are extracted by cation-exchange solid phase extraction. The drugs from the solid phase cartridge are eluted and the eluent is dried
Assay of NOS Activity by the Measurement of Conversion of Oxyhemoglobin to Methemoglobin by NO
such as Nω -nitro-L -arginine (L -NNA) and its methyl ester, L -NAME (3 ,4 ). Using the protocol described, this technique is sensitive (limit of detection approx 20 pmol/min per g tissue), specific for NOS in conjunction with the use of NOS inhibitors
The Use of Propidium Iodide to Assess Excitotoxic Neuronal Death in Primary Mixed Cortical Cultures
(nNOS). Thus, for the purposes of this chapter, the insult used to induce cell death will be various concentrations of NMDA and the compound used to demonstrate neuroprotection will be the nonspecific NOS inhibitor N ω-nitro-L
技术资料