- ¥2980
- LMAI Bio
- LM-4263R-FITC
- 中国/美国/欧洲
- 2025年07月11日
- ICC=1:50-200 IF=1:50-200
- Human, Mouse, Rat, Dog, Rabbit,
- Human, Mouse, Rat, Dog, Rabbit,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 靶点：
详见说明书
- 级别：
1
- 目录编号：
LM-4263R-FITC
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Anti-epithelial Sodium Channel gamma/FITC
- 抗体名：
Anti-epithelial Sodium Channel gamma/FITC
- 标记物：
FITC标记
- 宿主：
Human, Mouse, Rat, Dog, Rabbit,
- 适应物种：
Human, Mouse, Rat, Dog, Rabbit,
- 免疫原：
详见说明书
- 亚型：
IGg
- 形态：
粉末、液体、冻干粉
- 应用范围：
ICC=1:50-200 IF=1:50-200
- 浓度：
1mg/ml
- 保存条件：
-20 °C
- 规格：
100ul
| 英文名称 | Anti-epithelial Sodium Channel gamma/FITC |
| 中文名称 | FITC标记的上皮钠离子通道蛋白γ/γENaC抗体 |
| 别 名 | Amiloride sensitive epithelial sodium channel gamma subunit; Amiloride sensitive sodium channel subunit gamma; ENaC gamma subunit; ENaCg; ENaCgamma; Epithelial Na(+) channel subunit gamma; Epithelial Na+ channel subunit gamma; Gamma ENaC; Gamma NaCH; Nonvoltage gated sodium channel 1 subunit gamma; PHA 1; PHA1; SCNEG; SCNN 1G; SCNN1G; Sodium channel nonvoltage gated 1 gamma; SCNNG_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 神经生物学 信号转导 通道蛋白 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 71kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human epithelial Sodium Channel gamma |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel’s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1). Function: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Subunit: Probable heterotrimer containing one alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. Subcellular Location: Apical cell membrane; Multi-pass membrane protein. Note=Apical membrane of epithelial cells. Post-translational modifications: Phosphorylated on serine and threonine residues. Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation. DISEASE: Defects in SCNN1G are a cause of Liddle syndrome (LIDDS) [MIM:177200]. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel. Defects in SCNN1G are the cause of bronchiectasis with or without elevated sweat chloride type 3 (BESC3) [MIM:613071]. A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases. Similarity: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily. Database links: Entrez Gene: 6340 Human Entrez Gene: 20278 Mouse Entrez Gene: 24768 Rat Omim: 600761 Human SwissProt: P51170 Human SwissProt: Q9WU39 Mouse SwissProt: Q28738 Rabbit SwissProt: P37091 Rat Unigene: 371727 Human Unigene: 35247 Mouse Unigene: 10360 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验，置250ml细胞培养瓶中，于37℃、5%CO2细胞培养箱中培养，根据细胞生长情况及时添加培养液。(2 ) TCRγδT细胞鉴定 用抗TCRγδ-FITC、抗CD44FITC和抗CD3PE与培养10天时收集的培养细胞直接染色后进行流式细胞仪检测分析，阴性对照为FITC标记的正常人IgG。(3) γδT细胞形态学观察 用数码相机拍摄培养2、10天时细胞生长状态和培养10天时的细胞的瑞氏染色后的形态并进行透射式电镜检查。(4) γδT细胞杀伤活性检测 用本室建立的乳酸脱氢酶释放法测定γδT
这类抗体只与 IgG 重链反应，通常不能和 IgA 或 IgM 任何表位反应。 注意：不是所有 anti-IgG, Fc 抗体和所有亚型的 IgG 反应能力一致。要找和四种 IgG 亚类反应能力差不多的 抗鼠IgG, Fc γ抗体的话，应当选羊抗鼠IgG( 亚类1+2a+2b+3), Fc γ特异性片段(min X Hu,Bov,Rb Sr Prot) 。 Anti-IgG ， F(ab ’)2 fragment specific 这类抗体和 IgG 的 F(ab
，通常分别位于第24～34、50～65、95～102位氨基酸。VL和VH的这三个HVR分别称为HVR1、HVR2和HVR3。经X线结晶衍射的研究分析证明，高变区确实为抗体与抗原结合的位置，因而称为决定簇互补区（complementarity-determining regi-on,CDR）。VL和VH的HVR1、HVR2和HVR3又可分别称为CDR1、CDR2和CDR3，一般的CDR3具有更高的高变程度。高变区也是Ig分子独特型决定簇（idiotypic determinants）主要存在的部位
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