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- 上海博湖
- BH-K22768
- 进口、国产
- 2025年07月15日
- WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 详见说明书
- 详见说明书
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- 文献和实验
- 技术资料
- 抗体名：
锌指转录因子Slug抗体图片
- 抗体英文名：
Anti-SNAI2/SLUG
- 靶点：
详见说明书
- 浓度：
1mg/1ml
- 应用范围：
WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 宿主：
详见说明书
- 供应商：
上海博湖
- 库存：
大量
- 级别：
详见说明书
- 目录编号：
详见说明书
- 抗原来源：
Rabbit
- 保质期：
详见说明书
- 适应物种：
详见说明书
- 标记物：
详见说明书
- 克隆性：
多克隆
- 保存条件：
Store at -20 °C
- 形态：
详见说明书
- 亚型：
IgG
- 免疫原：
KLH conjugated synthetic peptide derived from human Slug N-terminus
- 规格：
0.2ml/200μg
英文名称 Anti-SNAI2/SLUG
中文名称 锌指转录因子Slug抗体图片
别 名 Neural crest transcription factor Slug; Protein snail homolog 2; Slug (chicken homolog) zinc finger protein; Slug homolog zinc finger protein; Slug zinc finger protein; SLUGH 1; SLUGH; SLUGH1; SNAI 2; SNAI2; SNAI-2; SNAI2_HUMAN; Snail 2; Snail homolog 2; Snail2; Snail-2; WS 2D; WS2D; Zinc finger protein SLUG; Zinc finger protein SNAI2.
锌指转录因子Slug抗体图片浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit
产品类型 一抗
研究领域 肿瘤 免疫学 神经生物学 信号转导 转录调节因子
蛋白分子量 predicted molecular weight: 30kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Slug N-terminus
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
锌指转录因子Slug抗体图片产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008].
Function : Transcriptional repressor. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occluding (OCLN) and subsequent oncogenic transformation of epithelial cells.
Subunit : Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains).
Subcellular Location : Nucleus.
Tissue Specificity : Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle.
DISEASE : Defects in SNAI2 are the cause of Waardenburg syndrome type 2D (WS2D) . WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1
Similarity : Belongs to the snail C2H2-type zinc-finger protein family.
Contains 5 C2H2-type zinc fingers.
Database links : UniProtKB/Swiss-Prot: O43623.1
转录调节因子（Transcriptin Regulators）
锌指转录因子Slug主要用于消化系统肿瘤转移方面的研究。
锌指转录因子Slug抗体图片抗体的鉴定：
1）抗体的效价鉴定：不管是用于诊断还是用于治疗,制备抗体的目的都是要求较高效价。不同的抗原制备的抗体,要求的效价不一。鉴定效价的方法很多,包括有试管凝集反应,琼脂扩散试验,酶联免疫吸附试验等。常用的抗原所制备的抗体一般都有约成的鉴定效价的方法,以资比较。如制备抗抗体的效价,一般就采用琼脂扩散试验来鉴定。
2）抗体的特异性鉴定：抗体的特异性是指与相应抗原或近似抗原物质的识别能力。抗体的特异性高,它的识别能力就强。衡量特异性通常以交叉反应率来表示。交叉反应率可用竞争抑制试验测定。以不同浓度抗原和近似抗原分别做竞争抑制曲线,计算各自的结合率,求出各自在IC50时的浓度,并按公式计算交叉反应率。
如果所用抗原浓度IC50浓度为pg/管,而一些近似抗原物质的IC50浓度几乎是无穷大时,表示这一抗血清与其他抗原物质的交叉反应率近似为0,即该血清的特异性较好。
3）亲和力：是指抗体和抗原结合的牢固程度。亲和力的高低是由抗原分子的大小,抗体分子的结合位点与抗原决定簇之间立体构型的合适度决定的。有助于维持抗原抗体复合物稳定的分子间力有氢键,疏水键,侧链相反电荷基因的库仑力,范德华力和空间斥力。亲和力常以亲和常数K表示,K的单位是L/mol。抗体亲和力的测定对抗体的筛选,确定抗体的用途,验证抗体的均一性等均有重要意义。
种属：
兔抗单克隆抗体，鼠抗单克隆抗体。兔抗多克隆抗体。抗体的浓度为1mg/ml。 抗体及相关标记抗体：HRP标记抗体，Biotin标记抗体，Gold标记抗体，RBITC标记抗体，AP标记抗体,FITC标记抗体，Cy3标记抗体，Cy5标记抗体，Cy5.5标记抗体，Cy7标记抗体，PE标记抗体，PE-Cy3标记抗体，PE-Cy5标记抗体，PE-Cy5.5标记抗体，PE-Cy7标记抗体，APC标记抗体，AlexaFluor 350标记抗体，Alexa Fluor 488标记抗体，Alexa Fluor 555标记抗体，Alexa Fluor647标记抗体 抗体的交叉反应： 人，小鼠，大鼠，鸡 ，狗，猪，羊，牛，兔等...... 抗体的应用：可以用于做石蜡切片免疫组化，冰冻切片免疫组化，Elisa，WB，免疫荧光等实验。
锌指转录因子Slug抗体图片实验原理 :
（1）特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以清除病原微生物或导致病理损伤。然而，抗体可通过与病毒或毒素的特异性结合，直接发挥中和病毒的作用。
（2）活补体：IgM、IgG1、IgG2和IgG3可通过经典途径激活补体，凝聚的IgA、IgG4和IgE可通过替代途径激活补体。
（3）结合细胞：不同类别的免疫球蛋白，可结合不同种的细胞，参与免疫应答。
（4）可通过胎盘及粘膜：免疫球蛋白G（IgG）能通过胎盘进入胎儿血流中，使胎儿形成自然被动
免疫。免疫球蛋白A（IgA）可通过消化道及呼吸道粘膜，是粘膜局部抗感染免疫的主要因素。
（5）具有抗原性：抗体分子是一种蛋白质，也具有刺机体产生免疫应答的性能。不同的免疫球蛋白分子，各具有不同的抗原性。
（6）抗体对理化因子的抵抗力与一般球蛋白相同：不耐热，60～70℃即被破坏。各种酶及能使蛋白质凝固变性的物质，均能破坏抗体的作用。抗体可被中性盐类沉淀。在上常可用硫酸铵或硫酸钠从免疫血清中沉淀出含有抗体的球蛋白，再经透析法将其纯化。
Fibulin 1 衰老关键蛋白抗原Multi-class antibodies规格： 0.5mg
癌易感基因1抗体(人) Anti-BRCA1 0.1ml
Rhesus antibody Rh Phospho-Doublecortin (Ser297) 化双皮质素抗体 规格 0.1ml
PVDF膜(30cm×3m 0.45um) 1卷 Millipore
ZNHIT1 英文名称： 细胞周期蛋白1结合蛋白抗体 0.2ml
DCP1A 英文名称： 脱帽酶1A抗体 0.2ml
癌易感基因1抗体(人) Anti-BRCA1 0.1ml
EV71(Human enterovirus 71)VP1(CT) 肠道病毒71型/手足口病病毒抗原(C端)Multi-class antibodies规格： 0.5mg
p53正向细胞凋亡调控因子抗体 Anti-BBC3/PUMA 0.1ml
Rhesus antibody Rh phospho-EGFR (Se90) 化表皮生长因子受体抗体 规格 0.1ml
DMEM高糖(含酸) 10×1L Gibco
ZNF843 英文名称： 指蛋白843抗体 0.2ml
Dystrobrevin alpha 英文名称： 肌营养蛋白α抗体 0.2ml
p53正向细胞凋亡调控因子抗体 Anti-BBC3/PUMA 0.1ml
ZDHHC17 英文名称： NFκB激活蛋白205抗体 0.1ml
DIS3L2 英文名称： 有丝分裂控制蛋白样DIS3L2抗体 0.2ml
化雄激素受体抗体 Anti-phospho-AR 0.1ml
Anti-CEA/Biotin 生物素化鼠抗人癌胚抗原单克隆抗体(检测)IgGMulti-class antibodies规格： 0.2ml
Rhesus antibody Rh phospho-EIF4G1(Se38) 化真核翻译起始因子4G抗体 规格 0.1ml
EAAT3(Excitatory amino acid transporters 3) 胶质细胞谷酸运载蛋白3抗原Multi-class antibodies规格： 0.5mg
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008].
Function : RasGRP1 is a Ras-specific exchange factor, which is activated by T-cell receptor (TCR) and promotes TCR-dependent positive selection of thymocytes. RasGRP1 is highly expressed on most T lymphocytic leukemias and is a common site of proviral insertion in retrovirus-induced murine T-cell lymphomas.
Subunit : Forms a signaling complex with DGKZ and HRAS. Interacts with F-actin. Interacts with SKAP1.
Subcellular Location : Cell Membrane, Cytoplasmic, Endoplasmic reticulum and Golgi Apparatus. Found in membrane fraction. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor.
Tissue Specificity : Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level).
DISEASE : Defects in RASGRP1 may contribute to susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Note=Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.
Similarity : Belongs to the RASGRP family.
Contains 2 EF-hand domains.
Contains 1 N-terminal Ras-GEF domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 Ras-GEF domain.
Database links : UniProtKB/Swiss-Prot: O95267.2
Anti-Socs 3/FITC 荧光素标记细胞因子信号传导抑制蛋白3抗体IgGMulti-class antibodies规格： 0.2ml
phospho-CREB-1 化环腺苷酸应答元件结合蛋白(多肽)Multi-class antibodies规格： 0.1mg
食欲素受体抗体 Anti-OXR 1ml
SERPINB3 英文名称： 丝酸蛋白酶抑制剂B3抗体 0.2ml
phospho-EGFR (Ty25) 英文名称： 化表皮生长因子受体抗体 0.1ml
Rhesus antibody Rh Phospho-NMDAR1(Ser896) 化谷酸受体1抗体 规格 0.1ml
phospho-CREB-1 化环腺苷酸应答元件结合蛋白(多肽)Multi-class antibodies规格： 0.1mg
锌指转录因子Slug抗体图片SCN9A/NAV1.7(Sodium channel protein type 9 subunit alpha) 电压开启的离子通道SCN9A抗原Multi-class antibodies规格： 0.5mg
Anti-BCHE 丁酰胆碱酯酶单克隆抗体Multi-class antibodies规格： 0.2ml
Rhesus antibody Rh PHAPI2/APRIL 酸性核磷蛋白32家族B抗体 规格 0.2ml
HIF-1alpha 浓缩液 0.1ml 进口分装
UGT1A9 英文名称： 尿苷二葡萄糖醛酸转移酶1A9 0.2ml
Complement C3b alpha' chain 英文名称： 补体C3b-α链抗体 0.1ml
Anti-BCHE 丁酰胆碱酯酶单克隆抗体Multi-class antibodies规格： 0.2ml
中文名称 锌指转录因子Slug抗体图片
别 名 Neural crest transcription factor Slug; Protein snail homolog 2; Slug (chicken homolog) zinc finger protein; Slug homolog zinc finger protein; Slug zinc finger protein; SLUGH 1; SLUGH; SLUGH1; SNAI 2; SNAI2; SNAI-2; SNAI2_HUMAN; Snail 2; Snail homolog 2; Snail2; Snail-2; WS 2D; WS2D; Zinc finger protein SLUG; Zinc finger protein SNAI2.
锌指转录因子Slug抗体图片浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit
产品类型 一抗
研究领域 肿瘤 免疫学 神经生物学 信号转导 转录调节因子
蛋白分子量 predicted molecular weight: 30kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Slug N-terminus
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
锌指转录因子Slug抗体图片产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008].
Function : Transcriptional repressor. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occluding (OCLN) and subsequent oncogenic transformation of epithelial cells.
Subunit : Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains).
Subcellular Location : Nucleus.
Tissue Specificity : Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle.
DISEASE : Defects in SNAI2 are the cause of Waardenburg syndrome type 2D (WS2D) . WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1
Similarity : Belongs to the snail C2H2-type zinc-finger protein family.
Contains 5 C2H2-type zinc fingers.
Database links : UniProtKB/Swiss-Prot: O43623.1
转录调节因子（Transcriptin Regulators）
锌指转录因子Slug主要用于消化系统肿瘤转移方面的研究。
锌指转录因子Slug抗体图片抗体的鉴定：
1）抗体的效价鉴定：不管是用于诊断还是用于治疗,制备抗体的目的都是要求较高效价。不同的抗原制备的抗体,要求的效价不一。鉴定效价的方法很多,包括有试管凝集反应,琼脂扩散试验,酶联免疫吸附试验等。常用的抗原所制备的抗体一般都有约成的鉴定效价的方法,以资比较。如制备抗抗体的效价,一般就采用琼脂扩散试验来鉴定。
2）抗体的特异性鉴定：抗体的特异性是指与相应抗原或近似抗原物质的识别能力。抗体的特异性高,它的识别能力就强。衡量特异性通常以交叉反应率来表示。交叉反应率可用竞争抑制试验测定。以不同浓度抗原和近似抗原分别做竞争抑制曲线,计算各自的结合率,求出各自在IC50时的浓度,并按公式计算交叉反应率。
如果所用抗原浓度IC50浓度为pg/管,而一些近似抗原物质的IC50浓度几乎是无穷大时,表示这一抗血清与其他抗原物质的交叉反应率近似为0,即该血清的特异性较好。
3）亲和力：是指抗体和抗原结合的牢固程度。亲和力的高低是由抗原分子的大小,抗体分子的结合位点与抗原决定簇之间立体构型的合适度决定的。有助于维持抗原抗体复合物稳定的分子间力有氢键,疏水键,侧链相反电荷基因的库仑力,范德华力和空间斥力。亲和力常以亲和常数K表示,K的单位是L/mol。抗体亲和力的测定对抗体的筛选,确定抗体的用途,验证抗体的均一性等均有重要意义。
种属：
兔抗单克隆抗体，鼠抗单克隆抗体。兔抗多克隆抗体。抗体的浓度为1mg/ml。 抗体及相关标记抗体：HRP标记抗体，Biotin标记抗体，Gold标记抗体，RBITC标记抗体，AP标记抗体,FITC标记抗体，Cy3标记抗体，Cy5标记抗体，Cy5.5标记抗体，Cy7标记抗体，PE标记抗体，PE-Cy3标记抗体，PE-Cy5标记抗体，PE-Cy5.5标记抗体，PE-Cy7标记抗体，APC标记抗体，AlexaFluor 350标记抗体，Alexa Fluor 488标记抗体，Alexa Fluor 555标记抗体，Alexa Fluor647标记抗体 抗体的交叉反应： 人，小鼠，大鼠，鸡 ，狗，猪，羊，牛，兔等...... 抗体的应用：可以用于做石蜡切片免疫组化，冰冻切片免疫组化，Elisa，WB，免疫荧光等实验。
锌指转录因子Slug抗体图片实验原理 :
（1）特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以清除病原微生物或导致病理损伤。然而，抗体可通过与病毒或毒素的特异性结合，直接发挥中和病毒的作用。
（2）活补体：IgM、IgG1、IgG2和IgG3可通过经典途径激活补体，凝聚的IgA、IgG4和IgE可通过替代途径激活补体。
（3）结合细胞：不同类别的免疫球蛋白，可结合不同种的细胞，参与免疫应答。
（4）可通过胎盘及粘膜：免疫球蛋白G（IgG）能通过胎盘进入胎儿血流中，使胎儿形成自然被动
免疫。免疫球蛋白A（IgA）可通过消化道及呼吸道粘膜，是粘膜局部抗感染免疫的主要因素。
（5）具有抗原性：抗体分子是一种蛋白质，也具有刺机体产生免疫应答的性能。不同的免疫球蛋白分子，各具有不同的抗原性。
（6）抗体对理化因子的抵抗力与一般球蛋白相同：不耐热，60～70℃即被破坏。各种酶及能使蛋白质凝固变性的物质，均能破坏抗体的作用。抗体可被中性盐类沉淀。在上常可用硫酸铵或硫酸钠从免疫血清中沉淀出含有抗体的球蛋白，再经透析法将其纯化。
Fibulin 1 衰老关键蛋白抗原Multi-class antibodies规格： 0.5mg
癌易感基因1抗体(人) Anti-BRCA1 0.1ml
Rhesus antibody Rh Phospho-Doublecortin (Ser297) 化双皮质素抗体 规格 0.1ml
PVDF膜(30cm×3m 0.45um) 1卷 Millipore
ZNHIT1 英文名称： 细胞周期蛋白1结合蛋白抗体 0.2ml
DCP1A 英文名称： 脱帽酶1A抗体 0.2ml
癌易感基因1抗体(人) Anti-BRCA1 0.1ml
EV71(Human enterovirus 71)VP1(CT) 肠道病毒71型/手足口病病毒抗原(C端)Multi-class antibodies规格： 0.5mg
p53正向细胞凋亡调控因子抗体 Anti-BBC3/PUMA 0.1ml
Rhesus antibody Rh phospho-EGFR (Se90) 化表皮生长因子受体抗体 规格 0.1ml
DMEM高糖(含酸) 10×1L Gibco
ZNF843 英文名称： 指蛋白843抗体 0.2ml
Dystrobrevin alpha 英文名称： 肌营养蛋白α抗体 0.2ml
p53正向细胞凋亡调控因子抗体 Anti-BBC3/PUMA 0.1ml
ZDHHC17 英文名称： NFκB激活蛋白205抗体 0.1ml
DIS3L2 英文名称： 有丝分裂控制蛋白样DIS3L2抗体 0.2ml
化雄激素受体抗体 Anti-phospho-AR 0.1ml
Anti-CEA/Biotin 生物素化鼠抗人癌胚抗原单克隆抗体(检测)IgGMulti-class antibodies规格： 0.2ml
Rhesus antibody Rh phospho-EIF4G1(Se38) 化真核翻译起始因子4G抗体 规格 0.1ml
EAAT3(Excitatory amino acid transporters 3) 胶质细胞谷酸运载蛋白3抗原Multi-class antibodies规格： 0.5mg
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008].
Function : RasGRP1 is a Ras-specific exchange factor, which is activated by T-cell receptor (TCR) and promotes TCR-dependent positive selection of thymocytes. RasGRP1 is highly expressed on most T lymphocytic leukemias and is a common site of proviral insertion in retrovirus-induced murine T-cell lymphomas.
Subunit : Forms a signaling complex with DGKZ and HRAS. Interacts with F-actin. Interacts with SKAP1.
Subcellular Location : Cell Membrane, Cytoplasmic, Endoplasmic reticulum and Golgi Apparatus. Found in membrane fraction. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor.
Tissue Specificity : Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level).
DISEASE : Defects in RASGRP1 may contribute to susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Note=Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.
Similarity : Belongs to the RASGRP family.
Contains 2 EF-hand domains.
Contains 1 N-terminal Ras-GEF domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 Ras-GEF domain.
Database links : UniProtKB/Swiss-Prot: O95267.2
Anti-Socs 3/FITC 荧光素标记细胞因子信号传导抑制蛋白3抗体IgGMulti-class antibodies规格： 0.2ml
phospho-CREB-1 化环腺苷酸应答元件结合蛋白(多肽)Multi-class antibodies规格： 0.1mg
食欲素受体抗体 Anti-OXR 1ml
SERPINB3 英文名称： 丝酸蛋白酶抑制剂B3抗体 0.2ml
phospho-EGFR (Ty25) 英文名称： 化表皮生长因子受体抗体 0.1ml
Rhesus antibody Rh Phospho-NMDAR1(Ser896) 化谷酸受体1抗体 规格 0.1ml
phospho-CREB-1 化环腺苷酸应答元件结合蛋白(多肽)Multi-class antibodies规格： 0.1mg
锌指转录因子Slug抗体图片SCN9A/NAV1.7(Sodium channel protein type 9 subunit alpha) 电压开启的离子通道SCN9A抗原Multi-class antibodies规格： 0.5mg
Anti-BCHE 丁酰胆碱酯酶单克隆抗体Multi-class antibodies规格： 0.2ml
Rhesus antibody Rh PHAPI2/APRIL 酸性核磷蛋白32家族B抗体 规格 0.2ml
HIF-1alpha 浓缩液 0.1ml 进口分装
UGT1A9 英文名称： 尿苷二葡萄糖醛酸转移酶1A9 0.2ml
Complement C3b alpha' chain 英文名称： 补体C3b-α链抗体 0.1ml
Anti-BCHE 丁酰胆碱酯酶单克隆抗体Multi-class antibodies规格： 0.2ml
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文献和实验相关实验
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模型的子代小鼠心脏中，也检测到了 NF-κB 通路的激活。 MARS 催化 GATA4 发生 K-Hcy 修饰，抑制其转录因子活性 作者接下来探究 K-Hcy 的上升如何导致心脏发育异常。作者通过筛选发现心脏发育关键的转录因子 GATA4 与 MARS 存在相互作用，MARS 结合 GATA4 并催化其 K300 位点发生 K-Hcy 修饰，该位点位于其锌指结构域附近，K-Hcy 的存在抑制了 GATA4 结合 DNA 的能力，其转录因子活性受到抑制。作者进一步通过位点突变等实验证实棕榈
人工设计转录因子来调控目标基因的表达已经不是梦想，基于锌指蛋白结构域的设计已经展开。锌指蛋白结构域能够结合于特定的三个碱基配对的DNA序列上。RNA干扰和反义核酸技术能够抑制基因的表达，而人工设计转录因子能够升高目标基因的表达，从而为疾病的新治疗方法开辟了新的思路。Nature Biotechnology上新发表的两篇文章为基于锌指蛋白结构域的转录因子设计提出了新的观点。 Kim et al.在整个基因组范围内寻找编码锌指蛋白结构域的序列
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锌指转录因子Slug抗体图片
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