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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
磷酸化1型神经纤维瘤抗体
- 抗体英文名：
Anti-phospho-NF1(Ser2817)
- 靶点：
详见说明书
- 浓度：
1mg/1ml
- 应用范围：
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 宿主：
详见说明书
- 供应商：
上海一研
- 库存：
31
- 级别：
详见说明书
- 目录编号：
详见说明书
- 抗原来源：
Rabbit
- 保质期：
详见说明书
- 适应物种：
详见说明书
- 标记物：
详见说明书
- 克隆性：
多克隆
- 保存条件：
Store at -20 °C
- 形态：
详见说明书
- 亚型：
IgG
- 免疫原：
KLH conjugated Synthesised phosphopeptide derived from human NF1 around the phosphorylation site of Ser2817
- 规格：
0.1ml/100μg
公司专业供应的抗体， 磷酸化1型神经纤维瘤抗体是用于化学反应、分析化验、研究实验、教学实 验、化学配方使用的纯净化学品，产品品质卓越，价格实惠，多种规格供应，售后完善。
英文名称 Anti-phospho-NF1(Ser2817)
中文名称 磷酸化1型神经纤维瘤抗体
别 名 NF1(phospho S2741); DKFZp686J1293; FLJ21220; Neurofibromatosis Noonan syndrome; Neurofibromatosis related protein NF 1; Neurofibromatosis related protein NF1; neurofibromatosis type I; Neurofibromatosis-related protein NF-1; Neurofibromin 1; Neurofibromin truncated; Neurofibromin1; NF 1; NF; NF1; NF1_HUMAN; NFNS; Type 1 Neurofibromatosis; von Recklinghausen disease neurofibromin; von Recklinghausen disease related protein VRNF; VRNF; WATS; Watson disease related protein WSS; Watson syndrome; WSS.
浓 度 1mg/1ml
规 格 0.1ml/100μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Rabbit
产品类型 一抗 磷酸化抗体
研究领域 肿瘤 细胞生物 免疫学 染色质和核信号 神经生物学 信号转导 表观遗传学 G蛋白信号
蛋白分子量 predicted molecular weight：
147/319kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human NF1 around the phosphorylation site of Ser2817
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Neurofibromin is a product of the tumor suppressor gene, Neurofibromatosis type I. Neurofibromin is known to have GTPase activity that modulates the ras pathway. The absence of or alteration of the neurofibromin protein may lead to Neurofibromatosis disease. This protein has not been purified, therefore, most of the information regarding this protein has been deduced from homology analysis of its gene sequence.
Function ：
Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
DISEASE : Neurofibromatosis 1 (NF1) [MIM:162200]: A disease characterized by patches of skin pigmentation (cafe-au-lait spots), Lisch nodules of the iris, tumors in the peripheral nervous system and fibromatous skin tumors. Individuals with the disorder have increased susceptibility to the development of benign and malignant tumors. Note=The disease is caused by mutations affecting the gene represented in this entry.
Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. Note=The disease is caused by mutations affecting the gene represented in this entry.
Watson syndrome (WS) [MIM:193520]: A syndrome characterized by the presence of pulmonary stenosis, cafe-au-lait spots, and mental retardation. It is considered as an atypical form of neurofibromatosis. Note=The disease is caused by mutations affecting the gene represented in this entry.
Familial spinal neurofibromatosis (FSNF) [MIM:162210]: Considered to be an alternative form of neurofibromatosis, showing multiple spinal tumors. Note=The disease is caused by mutations affecting the gene represented in this entry.
Neurofibromatosis-Noonan syndrome (NFNS) [MIM:601321]: Characterized by manifestations of both NF1 and Noonan syndrome (NS). NS is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. Note=The disease is caused by mutations affecting the gene represented in this entry.
Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene represented in this entry may be involved in disease pathogenesis.
Similarity ：
Contains 1 CRAL-TRIO domain.
Contains 1 Ras-GAP domain.
Database links : UniProtKB/Swiss-Prot: P21359.2
磷酸化1型神经纤维瘤抗体几种抗体概述：
1.抗角蛋白抗体（AKA），又称为抗丝集蛋白抗体或抗角质层抗体。AKA是类风湿关节炎早期诊断和判断预后的指标之一,其对RA患者的诊断的特异性为94% ,而其敏感性为47% ,并是一种鉴别RA和与多发性关节炎相关的丙型肝炎患者的有效检验标记物。
2.抗核周因子( APF)， 是定位于口腔黏附膜细胞胞质内的颗粒性蛋白复合物。可在RA患者的血清和关节液中测出，与性别、年龄无关。APF显示了较强的特异性（73%～99%）和敏感性。用间接免疫荧光法检测，方法精密度较差。
3.抗环瓜氨酸肽抗体（CCP），具有相对好的敏感度和特异性。其实，抗核周因子和抗角蛋白抗体，与CCP在化学结构上具有相关性，它们的表位都含有瓜氨酸，称为瓜氨酸相关自身免疫系统。
实验原理 :
（1）特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以清除病原微生物或导致病理损伤。然而，抗体可通过与病毒或毒素的特异性结合，直接发挥中和病毒的作用。
（2）活补体：IgM、IgG1、IgG2和IgG3可通过经典途径激活补体，凝聚的IgA、IgG4和IgE可通过替代途径激活补体。
（3）结合细胞：不同类别的免疫球蛋白，可结合不同种的细胞，参与免疫应答。
（4）可通过胎盘及粘膜：免疫球蛋白G（IgG）能通过胎盘进入胎儿血流中，使胎儿形成自然被动
免疫。免疫球蛋白A（IgA）可通过消化道及呼吸道粘膜，是粘膜局部抗感染免疫的主要因素。
（5）具有抗原性：抗体分子是一种蛋白质，也具有刺机体产生免疫应答的性能。不同的免疫球蛋白分子，各具有不同的抗原性。
（6）抗体对理化因子的抵抗力与一般球蛋白相同：不耐热，60～70℃即被破坏。各种酶及能使蛋白质凝固变性的物质，均能破坏抗体的作用。抗体可被中性盐类沉淀。在上常可用硫酸铵或硫酸钠从免疫血清中沉淀出含有抗体的球蛋白，再经透析法将其纯化。
HPV33 E7 人类状瘤病毒33抗体 特价促销
PHGDH 磷酸甘油酸脱氢酶抗体 特价促销
PASK/STK39 丝氨酸/苏氨酸蛋白激酶39抗体 特价促销
HES1 转录因子HES-1抗体 特价促销
Factor VIII 第八因子抗体 特价促销
Noggin 指(趾)关节粘连NOG蛋白抗体 特价促销
GGT1/CD224 γ谷氨酰转移酶抗体 特价促销
TAGL2/TAGLN2 细胞骨架相关蛋白2抗体 特价促销
Peroxiredoxin 2/PRXII 硫氧还蛋白过氧化物酶Ⅱ/巯基抗氧化蛋白抗体 特价促销
IL-8/CXCL8 白介素8抗体 特价促销
VIP Receptor 1/VAPC1 血管活性肠肽受体-1抗体 特价促销
Desmocollin 2 桥粒糖蛋白2/桥粒糖蛋白3抗体 特价促销
磷酸化1型神经纤维瘤抗体AFP / alpha-fetoprotein 抗體 (APC), 鼠單抗 现货促销
AFP / alpha-fetoprotein 抗體 (PE), 鼠單抗 现货促销
AFP / alpha-fetoprotein 抗體 (PE), 鼠單抗 现货促销
AFP / alpha-fetoprotein 抗體, 鼠單抗 现货促销
AFP / alpha-fetoprotein 抗體, 鼠單抗 现货促销
AFP / alpha-fetoprotein 抗體, 鼠單抗 现货促销
AFP / alpha-fetoprotein 抗體, 鼠單抗 现货促销
英文名称 Anti-phospho-NF1(Ser2817)
中文名称 磷酸化1型神经纤维瘤抗体
别 名 NF1(phospho S2741); DKFZp686J1293; FLJ21220; Neurofibromatosis Noonan syndrome; Neurofibromatosis related protein NF 1; Neurofibromatosis related protein NF1; neurofibromatosis type I; Neurofibromatosis-related protein NF-1; Neurofibromin 1; Neurofibromin truncated; Neurofibromin1; NF 1; NF; NF1; NF1_HUMAN; NFNS; Type 1 Neurofibromatosis; von Recklinghausen disease neurofibromin; von Recklinghausen disease related protein VRNF; VRNF; WATS; Watson disease related protein WSS; Watson syndrome; WSS.
浓 度 1mg/1ml
规 格 0.1ml/100μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Rabbit
产品类型 一抗 磷酸化抗体
研究领域 肿瘤 细胞生物 免疫学 染色质和核信号 神经生物学 信号转导 表观遗传学 G蛋白信号
蛋白分子量 predicted molecular weight：
147/319kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human NF1 around the phosphorylation site of Ser2817
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Neurofibromin is a product of the tumor suppressor gene, Neurofibromatosis type I. Neurofibromin is known to have GTPase activity that modulates the ras pathway. The absence of or alteration of the neurofibromin protein may lead to Neurofibromatosis disease. This protein has not been purified, therefore, most of the information regarding this protein has been deduced from homology analysis of its gene sequence.
Function ：
Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
DISEASE : Neurofibromatosis 1 (NF1) [MIM:162200]: A disease characterized by patches of skin pigmentation (cafe-au-lait spots), Lisch nodules of the iris, tumors in the peripheral nervous system and fibromatous skin tumors. Individuals with the disorder have increased susceptibility to the development of benign and malignant tumors. Note=The disease is caused by mutations affecting the gene represented in this entry.
Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. Note=The disease is caused by mutations affecting the gene represented in this entry.
Watson syndrome (WS) [MIM:193520]: A syndrome characterized by the presence of pulmonary stenosis, cafe-au-lait spots, and mental retardation. It is considered as an atypical form of neurofibromatosis. Note=The disease is caused by mutations affecting the gene represented in this entry.
Familial spinal neurofibromatosis (FSNF) [MIM:162210]: Considered to be an alternative form of neurofibromatosis, showing multiple spinal tumors. Note=The disease is caused by mutations affecting the gene represented in this entry.
Neurofibromatosis-Noonan syndrome (NFNS) [MIM:601321]: Characterized by manifestations of both NF1 and Noonan syndrome (NS). NS is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. Note=The disease is caused by mutations affecting the gene represented in this entry.
Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene represented in this entry may be involved in disease pathogenesis.
Similarity ：
Contains 1 CRAL-TRIO domain.
Contains 1 Ras-GAP domain.
Database links : UniProtKB/Swiss-Prot: P21359.2
磷酸化1型神经纤维瘤抗体几种抗体概述：
1.抗角蛋白抗体（AKA），又称为抗丝集蛋白抗体或抗角质层抗体。AKA是类风湿关节炎早期诊断和判断预后的指标之一,其对RA患者的诊断的特异性为94% ,而其敏感性为47% ,并是一种鉴别RA和与多发性关节炎相关的丙型肝炎患者的有效检验标记物。
2.抗核周因子( APF)， 是定位于口腔黏附膜细胞胞质内的颗粒性蛋白复合物。可在RA患者的血清和关节液中测出，与性别、年龄无关。APF显示了较强的特异性（73%～99%）和敏感性。用间接免疫荧光法检测，方法精密度较差。
3.抗环瓜氨酸肽抗体（CCP），具有相对好的敏感度和特异性。其实，抗核周因子和抗角蛋白抗体，与CCP在化学结构上具有相关性，它们的表位都含有瓜氨酸，称为瓜氨酸相关自身免疫系统。
实验原理 :
（1）特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以清除病原微生物或导致病理损伤。然而，抗体可通过与病毒或毒素的特异性结合，直接发挥中和病毒的作用。
（2）活补体：IgM、IgG1、IgG2和IgG3可通过经典途径激活补体，凝聚的IgA、IgG4和IgE可通过替代途径激活补体。
（3）结合细胞：不同类别的免疫球蛋白，可结合不同种的细胞，参与免疫应答。
（4）可通过胎盘及粘膜：免疫球蛋白G（IgG）能通过胎盘进入胎儿血流中，使胎儿形成自然被动
免疫。免疫球蛋白A（IgA）可通过消化道及呼吸道粘膜，是粘膜局部抗感染免疫的主要因素。
（5）具有抗原性：抗体分子是一种蛋白质，也具有刺机体产生免疫应答的性能。不同的免疫球蛋白分子，各具有不同的抗原性。
（6）抗体对理化因子的抵抗力与一般球蛋白相同：不耐热，60～70℃即被破坏。各种酶及能使蛋白质凝固变性的物质，均能破坏抗体的作用。抗体可被中性盐类沉淀。在上常可用硫酸铵或硫酸钠从免疫血清中沉淀出含有抗体的球蛋白，再经透析法将其纯化。
HPV33 E7 人类状瘤病毒33抗体 特价促销
PHGDH 磷酸甘油酸脱氢酶抗体 特价促销
PASK/STK39 丝氨酸/苏氨酸蛋白激酶39抗体 特价促销
HES1 转录因子HES-1抗体 特价促销
Factor VIII 第八因子抗体 特价促销
Noggin 指(趾)关节粘连NOG蛋白抗体 特价促销
GGT1/CD224 γ谷氨酰转移酶抗体 特价促销
TAGL2/TAGLN2 细胞骨架相关蛋白2抗体 特价促销
Peroxiredoxin 2/PRXII 硫氧还蛋白过氧化物酶Ⅱ/巯基抗氧化蛋白抗体 特价促销
IL-8/CXCL8 白介素8抗体 特价促销
VIP Receptor 1/VAPC1 血管活性肠肽受体-1抗体 特价促销
Desmocollin 2 桥粒糖蛋白2/桥粒糖蛋白3抗体 特价促销
磷酸化1型神经纤维瘤抗体AFP / alpha-fetoprotein 抗體 (APC), 鼠單抗 现货促销
AFP / alpha-fetoprotein 抗體 (PE), 鼠單抗 现货促销
AFP / alpha-fetoprotein 抗體 (PE), 鼠單抗 现货促销
AFP / alpha-fetoprotein 抗體, 鼠單抗 现货促销
AFP / alpha-fetoprotein 抗體, 鼠單抗 现货促销
AFP / alpha-fetoprotein 抗體, 鼠單抗 现货促销
AFP / alpha-fetoprotein 抗體, 鼠單抗 现货促销
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磷酸化1型神经纤维瘤抗体
询价
