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- 详细信息
- 技术资料
- 抗体名:
速激肽受体3抗体品牌
- 抗体英文名:
Anti-TACR3
- 靶点:
详见说明书
- 浓度:
1mg/1ml
- 应用范围:
WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 宿主:
详见说明书
- 供应商:
上海博湖
- 库存:
大量
- 级别:
详见说明书
- 目录编号:
详见说明书
- 抗原来源:
Rabbit
- 保质期:
详见说明书
- 适应物种:
详见说明书
- 标记物:
详见说明书
- 克隆性:
多克隆
- 保存条件:
Store at -20 °C
- 形态:
详见说明书
- 亚型:
IgG
- 免疫原:
KLH conjugated synthetic peptide derived from human TACR3
- 规格:
0.2ml/200μg
速激肽受体3抗体品牌20号染色体开放阅读框195抗体
7号染色体开放阅读框62抗体
9号染色体开放阅读框174抗体
6号染色体开放阅读框64抗体
免疫球蛋白G Fc段受体Ⅱ抗体
英文名称 Anti-TACR3
中文名称 速激肽受体3抗体品牌
别 名 MGC148060; MGC148061; Neurokinin B receptor; Neuromedin K Receptor; Neuromedin-K receptor; NK 3 receptor; NK-3 receptor; NK-3R; NK3 receptor; NK3R; NK3R_HUMAN; NK 3R; NK3 receptor; NK3R; NKR; TAC 3R; TAC3R; TAC3RL; Tachykinin receptor 3; TACR 3; TACR3.
速激肽受体3抗体品牌浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig
产品类型 一抗
研究领域 神经生物学
蛋白分子量 predicted molecular weight: 52kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human TACR3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
速激肽受体3抗体品牌产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the C-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.
Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g. G-protein coupled activation of phospholipase C).
Function : This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
Subcellular Location : Cell membrane; Multi-pass membrane protein.
Post-translational modifications : The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.
DISEASE : Hypogonadotropic hypogonadism 11 with or without anosmia (HH11) [MIM:614840]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity : Belongs to the G-protein coupled receptor 1 family.
Database links : UniProtKB/Swiss-Prot: P29371.1
P物质和NK同属于速激肽家族,而速激肽受体有NK-1、NK-2和NK-3,其中P物质与NK-1的亲和力最强。
速激肽受体3抗体品牌抗体的鉴定:
1)抗体的效价鉴定:不管是用于诊断还是用于治疗,制备抗体的目的都是要求较高效价。不同的抗原制备的抗体,要求的效价不一。鉴定效价的方法很多,包括有试管凝集反应,琼脂扩散试验,酶联免疫吸附试验等。常用的抗原所制备的抗体一般都有约成的鉴定效价的方法,以资比较。如制备抗抗体的效价,一般就采用琼脂扩散试验来鉴定。
2)抗体的特异性鉴定:抗体的特异性是指与相应抗原或近似抗原物质的识别能力。抗体的特异性高,它的识别能力就强。衡量特异性通常以交叉反应率来表示。交叉反应率可用竞争抑制试验测定。以不同浓度抗原和近似抗原分别做竞争抑制曲线,计算各自的结合率,求出各自在IC50时的浓度,并按公式计算交叉反应率。
如果所用抗原浓度IC50浓度为pg/管,而一些近似抗原物质的IC50浓度几乎是无穷大时,表示这一抗血清与其他抗原物质的交叉反应率近似为0,即该血清的特异性较好。
3)亲和力:是指抗体和抗原结合的牢固程度。亲和力的高低是由抗原分子的大小,抗体分子的结合位点与抗原决定簇之间立体构型的合适度决定的。有助于维持抗原抗体复合物稳定的分子间力有氢键,疏水键,侧链相反电荷基因的库仑力,范德华力和空间斥力。亲和力常以亲和常数K表示,K的单位是L/mol。抗体亲和力的测定对抗体的筛选,确定抗体的用途,验证抗体的均一性等均有重要意义。
种属:
兔抗单克隆抗体,鼠抗单克隆抗体。兔抗多克隆抗体。抗体的浓度为1mg/ml。 抗体及相关标记抗体:HRP标记抗体,Biotin标记抗体,Gold标记抗体,RBITC标记抗体,AP标记抗体,FITC标记抗体,Cy3标记抗体,Cy5标记抗体,Cy5.5标记抗体,Cy7标记抗体,PE标记抗体,PE-Cy3标记抗体,PE-Cy5标记抗体,PE-Cy5.5标记抗体,PE-Cy7标记抗体,APC标记抗体,AlexaFluor 350标记抗体,Alexa Fluor 488标记抗体,Alexa Fluor 555标记抗体,Alexa Fluor647标记抗体 抗体的交叉反应: 人,小鼠,大鼠,鸡 ,狗,猪,羊,牛,兔等...... 抗体的应用:可以用于做石蜡切片免疫组化,冰冻切片免疫组化,Elisa,WB,免疫荧光等实验。
缬酰-tRNA合成酶抗体 Anti-vars2 WB IHC-P IHC-F IF 100ul
化鸟嘌呤核苷酸交换因子VAV3抗体 Anti-phospho-VAV3 WB IHC-P IHC-F IF 100ul
棕榈酰化膜蛋白6抗体 Anti-MPP6 WB IHC-P IHC-F IF 100ul
鸟嘌呤核苷酸交换因子VAV3抗体 Anti-VAV3 WB IHC-P IHC-F IF 100ul
突触小泡膜蛋白同源样蛋白1抗体 Anti-KIAA1576 WB IHC
致癌基因C-Myc抗体 Anti-C-Myc WB IHC-P IHC-F IF 100ul
胆囊收缩素8抗体 Anti-CCK8 WB IHC-P IHC-F IF 100ul
结合转化激活因子CITED1抗体 Anti-CITED1 WB IHC-P IHC-F IF 100ul
CSMD2蛋白抗体 Anti-CSMD2 WB IHC-P IHC-F IF 100ul
CSMD3蛋白抗体 Anti-CSMD3 WB IHC-P IHC-F IF 100ul
腊样芽孢杆菌选择琼脂基础250g用于腊样芽孢杆菌选择性分离培养
肠道菌增菌肉汤(EE) Enterobacteria Enrichment Broth 用于肠道菌的增菌培养(GB标准)
改良马丁琼脂培养基 Martin Agar Medium ,Modified 250 用于生物制品霉菌无菌检验
碱性蛋白胨水APW250g/瓶用于嗜水气单胞菌增菌incubationmedia碱性蛋白胨水APW250g/瓶用于嗜水气单胞菌增菌
mEC肉汤 250g 用于0157选择性增菌(USDA-FSIS方法)
营养肉汤培养基(中国药典)250g用于药品中一般细菌的增菌培养
Hugh-Leifon葡萄糖肉汤(HLGB) 250(g) incubation media Hugh-Leifon葡萄糖肉汤(HLGB) 250(g)
胰酶牛肉汤 胰酶牛肉汤 1万毫升/袋 快疫疫苗用
碱性胆盐琼脂250用于分离霍乱弧菌incubationmedia碱性胆盐琼脂250用于分离霍乱弧菌
盐肉汤 250g 用于蜡样芽孢杆菌盐还原试验(SN标准)
速激肽受体3抗体品牌血琼脂培养基基础260250g加入脱纤维羊血或兔血,制成血琼脂培养基,用于营养要求较高的细菌的培养及溶血试验(GB4789..
卡里-布莱尔转运培养基 (CM0519) Oxoid incubation media 卡里-布莱尔转运培养基 (CM0519) Oxoid
苏云金芽孢杆菌戈尔斯德变种 模式菌株 支/瓶
m-TEC琼脂250g用于水中耐热细菌滤膜计数
MH肉汤(MHB) 250g 用于抗生素敏感试验
速激肽受体3抗体品牌实验原理 :
(1)特异性结合抗原:抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞,通常需要补体或吞噬细胞等共同发挥效应以清除病原微生物或导致病理损伤。然而,抗体可通过与病毒或毒素的特异性结合,直接发挥中和病毒的作用。
(2)活补体:IgM、IgG1、IgG2和IgG3可通过经典途径激活补体,凝聚的IgA、IgG4和IgE可通过替代途径激活补体。
(3)结合细胞:不同类别的免疫球蛋白,可结合不同种的细胞,参与免疫应答。
(4)可通过胎盘及粘膜:免疫球蛋白G(IgG)能通过胎盘进入胎儿血流中,使胎儿形成自然被动
免疫。免疫球蛋白A(IgA)可通过消化道及呼吸道粘膜,是粘膜局部抗感染免疫的主要因素。
(5)具有抗原性:抗体分子是一种蛋白质,也具有刺机体产生免疫应答的性能。不同的免疫球蛋白分子,各具有不同的抗原性。
(6)抗体对理化因子的抵抗力与一般球蛋白相同:不耐热,60~70℃即被破坏。各种酶及能使蛋白质凝固变性的物质,均能破坏抗体的作用。抗体可被中性盐类沉淀。在上常可用硫酸铵或硫酸钠从免疫血清中沉淀出含有抗体的球蛋白,再经透析法将其纯化。
7号染色体开放阅读框62抗体
9号染色体开放阅读框174抗体
6号染色体开放阅读框64抗体
免疫球蛋白G Fc段受体Ⅱ抗体
英文名称 Anti-TACR3
中文名称 速激肽受体3抗体品牌
别 名 MGC148060; MGC148061; Neurokinin B receptor; Neuromedin K Receptor; Neuromedin-K receptor; NK 3 receptor; NK-3 receptor; NK-3R; NK3 receptor; NK3R; NK3R_HUMAN; NK 3R; NK3 receptor; NK3R; NKR; TAC 3R; TAC3R; TAC3RL; Tachykinin receptor 3; TACR 3; TACR3.
速激肽受体3抗体品牌浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig
产品类型 一抗
研究领域 神经生物学
蛋白分子量 predicted molecular weight: 52kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human TACR3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
速激肽受体3抗体品牌产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the C-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.
Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g. G-protein coupled activation of phospholipase C).
Function : This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
Subcellular Location : Cell membrane; Multi-pass membrane protein.
Post-translational modifications : The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.
DISEASE : Hypogonadotropic hypogonadism 11 with or without anosmia (HH11) [MIM:614840]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity : Belongs to the G-protein coupled receptor 1 family.
Database links : UniProtKB/Swiss-Prot: P29371.1
P物质和NK同属于速激肽家族,而速激肽受体有NK-1、NK-2和NK-3,其中P物质与NK-1的亲和力最强。
速激肽受体3抗体品牌抗体的鉴定:
1)抗体的效价鉴定:不管是用于诊断还是用于治疗,制备抗体的目的都是要求较高效价。不同的抗原制备的抗体,要求的效价不一。鉴定效价的方法很多,包括有试管凝集反应,琼脂扩散试验,酶联免疫吸附试验等。常用的抗原所制备的抗体一般都有约成的鉴定效价的方法,以资比较。如制备抗抗体的效价,一般就采用琼脂扩散试验来鉴定。
2)抗体的特异性鉴定:抗体的特异性是指与相应抗原或近似抗原物质的识别能力。抗体的特异性高,它的识别能力就强。衡量特异性通常以交叉反应率来表示。交叉反应率可用竞争抑制试验测定。以不同浓度抗原和近似抗原分别做竞争抑制曲线,计算各自的结合率,求出各自在IC50时的浓度,并按公式计算交叉反应率。
如果所用抗原浓度IC50浓度为pg/管,而一些近似抗原物质的IC50浓度几乎是无穷大时,表示这一抗血清与其他抗原物质的交叉反应率近似为0,即该血清的特异性较好。
3)亲和力:是指抗体和抗原结合的牢固程度。亲和力的高低是由抗原分子的大小,抗体分子的结合位点与抗原决定簇之间立体构型的合适度决定的。有助于维持抗原抗体复合物稳定的分子间力有氢键,疏水键,侧链相反电荷基因的库仑力,范德华力和空间斥力。亲和力常以亲和常数K表示,K的单位是L/mol。抗体亲和力的测定对抗体的筛选,确定抗体的用途,验证抗体的均一性等均有重要意义。
种属:
兔抗单克隆抗体,鼠抗单克隆抗体。兔抗多克隆抗体。抗体的浓度为1mg/ml。 抗体及相关标记抗体:HRP标记抗体,Biotin标记抗体,Gold标记抗体,RBITC标记抗体,AP标记抗体,FITC标记抗体,Cy3标记抗体,Cy5标记抗体,Cy5.5标记抗体,Cy7标记抗体,PE标记抗体,PE-Cy3标记抗体,PE-Cy5标记抗体,PE-Cy5.5标记抗体,PE-Cy7标记抗体,APC标记抗体,AlexaFluor 350标记抗体,Alexa Fluor 488标记抗体,Alexa Fluor 555标记抗体,Alexa Fluor647标记抗体 抗体的交叉反应: 人,小鼠,大鼠,鸡 ,狗,猪,羊,牛,兔等...... 抗体的应用:可以用于做石蜡切片免疫组化,冰冻切片免疫组化,Elisa,WB,免疫荧光等实验。
缬酰-tRNA合成酶抗体 Anti-vars2 WB IHC-P IHC-F IF 100ul
化鸟嘌呤核苷酸交换因子VAV3抗体 Anti-phospho-VAV3 WB IHC-P IHC-F IF 100ul
棕榈酰化膜蛋白6抗体 Anti-MPP6 WB IHC-P IHC-F IF 100ul
鸟嘌呤核苷酸交换因子VAV3抗体 Anti-VAV3 WB IHC-P IHC-F IF 100ul
突触小泡膜蛋白同源样蛋白1抗体 Anti-KIAA1576 WB IHC
致癌基因C-Myc抗体 Anti-C-Myc WB IHC-P IHC-F IF 100ul
胆囊收缩素8抗体 Anti-CCK8 WB IHC-P IHC-F IF 100ul
结合转化激活因子CITED1抗体 Anti-CITED1 WB IHC-P IHC-F IF 100ul
CSMD2蛋白抗体 Anti-CSMD2 WB IHC-P IHC-F IF 100ul
CSMD3蛋白抗体 Anti-CSMD3 WB IHC-P IHC-F IF 100ul
腊样芽孢杆菌选择琼脂基础250g用于腊样芽孢杆菌选择性分离培养
肠道菌增菌肉汤(EE) Enterobacteria Enrichment Broth 用于肠道菌的增菌培养(GB标准)
改良马丁琼脂培养基 Martin Agar Medium ,Modified 250 用于生物制品霉菌无菌检验
碱性蛋白胨水APW250g/瓶用于嗜水气单胞菌增菌incubationmedia碱性蛋白胨水APW250g/瓶用于嗜水气单胞菌增菌
mEC肉汤 250g 用于0157选择性增菌(USDA-FSIS方法)
营养肉汤培养基(中国药典)250g用于药品中一般细菌的增菌培养
Hugh-Leifon葡萄糖肉汤(HLGB) 250(g) incubation media Hugh-Leifon葡萄糖肉汤(HLGB) 250(g)
胰酶牛肉汤 胰酶牛肉汤 1万毫升/袋 快疫疫苗用
碱性胆盐琼脂250用于分离霍乱弧菌incubationmedia碱性胆盐琼脂250用于分离霍乱弧菌
盐肉汤 250g 用于蜡样芽孢杆菌盐还原试验(SN标准)
速激肽受体3抗体品牌血琼脂培养基基础260250g加入脱纤维羊血或兔血,制成血琼脂培养基,用于营养要求较高的细菌的培养及溶血试验(GB4789..
卡里-布莱尔转运培养基 (CM0519) Oxoid incubation media 卡里-布莱尔转运培养基 (CM0519) Oxoid
苏云金芽孢杆菌戈尔斯德变种 模式菌株 支/瓶
m-TEC琼脂250g用于水中耐热细菌滤膜计数
MH肉汤(MHB) 250g 用于抗生素敏感试验
速激肽受体3抗体品牌实验原理 :
(1)特异性结合抗原:抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞,通常需要补体或吞噬细胞等共同发挥效应以清除病原微生物或导致病理损伤。然而,抗体可通过与病毒或毒素的特异性结合,直接发挥中和病毒的作用。
(2)活补体:IgM、IgG1、IgG2和IgG3可通过经典途径激活补体,凝聚的IgA、IgG4和IgE可通过替代途径激活补体。
(3)结合细胞:不同类别的免疫球蛋白,可结合不同种的细胞,参与免疫应答。
(4)可通过胎盘及粘膜:免疫球蛋白G(IgG)能通过胎盘进入胎儿血流中,使胎儿形成自然被动
免疫。免疫球蛋白A(IgA)可通过消化道及呼吸道粘膜,是粘膜局部抗感染免疫的主要因素。
(5)具有抗原性:抗体分子是一种蛋白质,也具有刺机体产生免疫应答的性能。不同的免疫球蛋白分子,各具有不同的抗原性。
(6)抗体对理化因子的抵抗力与一般球蛋白相同:不耐热,60~70℃即被破坏。各种酶及能使蛋白质凝固变性的物质,均能破坏抗体的作用。抗体可被中性盐类沉淀。在上常可用硫酸铵或硫酸钠从免疫血清中沉淀出含有抗体的球蛋白,再经透析法将其纯化。
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