重组小鼠IGFBP-6(胰岛素样生长因子结合蛋白6)

特别提示：包括重组小鼠IGFBP-6(胰岛素样生长因子结合蛋白6)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组小鼠IGFBP-6(胰岛素样生长因子结合蛋白6)
英文名称：Recombinant Mouse Insulin-Like Growth Factor-Binding Protein 6
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Ala26-Gly238在C端含有His标签。

IGFBP-6 质量控制：＞95%(还原性SDS-PAGE)

IGFBP-6 制剂：冻干品

IGFBP-6 保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

IGFBP-6 复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于IGFBP-6 ：
Insulin-like growth factors (IGFs) comprise a family of endo*(代"c")rine, paracrine and autocrine polypeptides consisting of the ligands IGF1 and IGF2, two receptors (IGF1R, IGF2R), at least 6 IGF-binding proteins (IGFBPs) and IGFBP proteases. Among the binding proteins, IGFBP6 is unique because of its N-terminal disulfide linkages and its marked binding preference for IGF2. It is a potent inhibitor of the interaction between IGF2 and its receptor IGF1R, thus preventing major functions of IGF2, such as induction of proliferation, differentiation, cell adhesion, or colony formation. In particular, IGFBP-6 inhibited the growth of neuroblastoma and rhabdomyosarcoma xenografts. GFBP-6 is expressed in many tissues, including lung, liver, gut and the central nervous system.