重组人TWSG1(原肠胚形成同源蛋白1)

特别提示：包括重组人TWSG1(原肠胚形成同源蛋白1)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人TWSG1(原肠胚形成同源蛋白1)
英文名称：Recombinant Human Twisted Gastrulation Protein Homolog 1
产品货号：JN0546
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Cys26-Phe223在C端含有His标签。

TWSG1质量控制：＞95%(还原性SDS-PAGE)

TWSG1制剂：冻干品

TWSG1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

TWSG1复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于TWSG1：
Twisted Gastrulation Protein Homolog 1 (TWSG1) is a 22 kDa secreted protein that belongs to the twisted gastrulation protein family. Human TWSG1 is synthesized as a 223 aa precursor that contains a 25 aa signal peptide and a 198 aa mature chain. TWSG1 may be involved in dorsoventral axis formation. TWSG1 seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors.TWSG1 can inhibit BMP activity by binding directly to BMP proteins, and can act the anti-BMP function, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. TWSG1 may be an important modulator of BMP-regulated cartilage development, chondrocyte differentiation and thymocyte development.

除了重组人TWSG1(原肠胚形成同源蛋白1),，我公司还供应以下相关产品：



名称：重组错配尿嘧啶DNA糖基化酶(Mug)
货号：JN1944
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目标蛋白包含序列(Met1-Arg168) of E.coli Mug.

Mug质量控制：＞95%(SEC-HPLC，还原性SDS-PAGE)

Mug制剂：液体

Mug保存：
收到后请置于-20℃以下，可保存长达6个月，避免反复冻融。

关于Mug：
E. coli Mismatch Uracil DNA Glycosylase (Mug protein) is an 18 kDa constitutively expressed protein which belongs to the TDG/mug DNA glycosylase family. It has been proposed that the Mug protein excises 3,N4-ethenocytosine and removes the uracil base from mismatches in the order of U:G>U:A, although the biological role remains unclear. Uracil bases in DNA can arise from deamination of cytosine giving rise to increased spontaneous mutations. The enzyme Uracil-N-Glycosylase removes uracil from the DNA leaving an AP site. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. It is required for DNA damage lesion repair in stationary-phase cells.